Neurolymphomatosis: A Rare Cause of Multiple Mononeuropathy
Gayathri Petluri, Manoj Kumar Goyal, Veenu Singla, Bhagwant Rai Mittal, Uma Nahar, Manish Modi, Nalini Gupta, Dheeraj Khurana
4Department of Histopathology, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Department of Neurology, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Department of Nuclear Medicine and PET, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Department of Radiodiagnosis, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
DOI: 10.4236/wjns.2014.42022   PDF   HTML     4,986 Downloads   6,561 Views   Citations


Neurolymphomatosis, defined as invasion of cranial nerves and peripheral nerve roots, plexus or nerves by Non Hodgkin’s Lymphoma is a very rare clinical entity. We describe a case of 69 years old gentleman, who presented to us with asymmetric, painful sensorimotor polyneuropathy. He was admitted with 2 months history of dry cough, constitutional symptoms, paraesthesias on right side of face along with painful asymmetrical quadriparesis. Nerve conduction studies were suggestive of asymmetrical sensorimotor axonal and demyelinating neuropathy. Cerebrospinal fluid analysis revealed mild pleocytosis with raised protein. FDG-PET showed intense uptake in both adrenals, abdominal lymph nodes, sacral nerve roots and brachial plexus. Fine needle aspiration cytology of adrenal mass revealed evidence of diffuse large B cell Non Hodgkin’s Lymphoma. As patient succumbed to illness, an autopsy was done, which revealed diffuse large B cell lymphoma involving adrenals, brachial and lumbosacral plexuses. Our report provides important insights into a rare cause of painful demyelinating multiple mononeuropathy and emphasises on increasing role and diagnostic utility of PET imaging in evaluation of patients presenting with multiple mononeuropathy, especially with regards to paraneoplastic or neoplastic causes such as lymphoma.

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Petluri, G. , Goyal, M. , Singla, V. , Mittal, B. , Nahar, U. , Modi, M. , Gupta, N. and Khurana, D. (2014) Neurolymphomatosis: A Rare Cause of Multiple Mononeuropathy. World Journal of Neuroscience, 4, 190-193. doi: 10.4236/wjns.2014.42022.

Conflicts of Interest

The authors declare no conflicts of interest.


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