Effect of Peripheral Arterial Disease on Serum Ischemia-Modified Albumin Levels in Type 2 Diabetic Patients


Background: The aim of this study is to evaluate the role of IMA and the effect of Type-2 diabetes in peripheral arterial ischemic patient. Methods: In our study, randomized patient groups to be undergone peripheral surgery, consisting of 16 diabetic and 12 non-diabetic patients diagnosed with peripheral arterial disease, have been examined. After standard anesthesia, the surgery was performed by the same surgical team, blood samples were taken before and after cross-clamp, and the levels of ischemia modified albumin (IMA), which is a new ischemic marker, were studied spectrophotometrically. Demographic data were compared with the type-2 diabetes association. Results: In this study, we found that there were no correlation with the ankle brachial index (ABI) and risk factors of diabetes between postoperative IMA levels (P: 0.47). Preoperative IMA serum blood levels were significantly higher in patients with peripheral arterial disease (P: 0.70), and positively associated with ABI (diabetic group P: 0.04, non-diabetic group P: 00). Also, no correlation was found with X clamp times, ABI, and IMA blood levels (P: 0.30). In diabetic group, ischemia marker increase was high and there was a positive correlation between HbA1c levels (P: 0.002). Conclusion: Our study suggested that, preoperative serum IMA levels were positively associated with ABI. In diabetic group, the increase in IMA levels was high and there was positive correlation between HbA1c levels. IMA was a benefit marker for monitoring and early diagnosis of the peripheral arterial disease.

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Gencpinar, T. , Ayoğlu, U. , Aykut, K. , Albayrak, G. , Ellidag, H. , Yılmaz, M. , Sağdıç, K. and Emmiler, M. (2014) Effect of Peripheral Arterial Disease on Serum Ischemia-Modified Albumin Levels in Type 2 Diabetic Patients. World Journal of Cardiovascular Surgery, 4, 81-86. doi: 10.4236/wjcs.2014.45013.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Hirsch, A.T., Haskal, Z.J., Hertzer, N.R., Bakal, C.W., Creager, M.A., Halperin, J.L., et al. (2006) ACC/AHA Guidelines for the Management of Patients with Peripheral Arterial Disease (Lower Extremity, Renal, Mesentery, and Abdominal Aortic). Circulation, 113, 1474-1547; and Journal of the American College of Cardiology, 47, 1239-1312.
[2] Bar-Or, D., Lau, E. and Winkler, J.V. (2000) A Novel Assay for Cobalt-Albumin Binding and Its Potential as a Marker for Myocardial Ischemia—A Preliminary Report. The Journal of Emergency Medicine, 19, 311-315.
[3] Norgren, L., Hiatt, W.R., Dormandy, J.A., Nehler, M.R., Harris, K.A., Fowkes, F.G., et al. (2007) Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). Journal of Vascular Surgery, 45, S5-S67.
[4] Kaefer, M., Piva, S.J., De Carvalho, J.A., Da Silva, D.B., Becker, A.M., Coelho, A.C., et al. (2010) Association between Ischemia Modified Albumin, Inflammation and Hyperglycemia in Type 2 Diabetes Mellitus. Clinical Biochemistry, 43, 450-454.
[5] O’Hare, A.M., Katz, R., Shlipak, M.G., Cushman, M. and Newman, A.B. (2006) Mortality and Cardiovascular Risk across the Ankle-Arm Index Spectrum: Results from the Cardiovascular Health Study. Circulation, 113, 388-393.
[6] Aronow, W.S., Ahn, C., Weiss, M.B. and Babu, S. (2007) Relation of Increased Hemoglobin A (1c) Levels to Severity of Peripheral Arterial Disease in Patients with Diabetes Mellitus. American Journal of Cardiology, 99, 1468-1469.
[7] Newman, A.B., Siscovick, D.S., Manolio, T.A., Polak, J., Fried, L.P., Borhani, N.O., et al. (1993) Ankle-Arm Index as a Marker of Atherosclerosis in the Cardiovascular Health Study. Circulation, 88, 837-845.
[8] Dahiya, K., Aggarwal, K., Seth, S., Singh, V. and Sharma, T.K. (2010) Type 2 Diabetes Mellitus without Vascular Complications and Ischemia Modified Albumin. Clinical Laboratory, 56, 187-190.
[9] Amstrong, D.G. and Lavery, L.A. (1998) Diabetic Foot Ulcers: Prevention, Diagnosis and Classification. American Family Physician, 57, 1325-1332.
[10] Gencpinar, T., Albayrak, G., Akgol, E., Metin, S.K., Ugurlu, S.B. and Hazan, E. (2013) Ischemia Modified Albumin Sensitivity of Coronary Artery Bypass Operation. Turkiye Klinikleri Cardiovascular Sciences, 25, 1-7.

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