Obesity, Diabetes Mellitus and Vascular Disease: A Complex Relationship with Prostate Cancer

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DOI: 10.4236/jct.2014.55050    3,493 Downloads   4,620 Views   Citations

ABSTRACT

Background: Obesity, type II Diabetes mellitus (DMII) and vascular damage could be implicated in prostate cancer (PCa) nevertheless no clear results has been reached. The aim of the research was to investigate the association of these alterations with PCa at initial diagnosis, without the influence of hormone therapy or chemotherapy. Methods: Retrospective analysis of 400 patients undergoing prostate biopsy at our institution between 2005 and 2012 was conducted. We examined associations of obesity, DMII and vascular damage in 200 patients with PCa diagnosis versus 200 age-matched controls. Men with history of hormone therapy or chemotherapy, prostate or bladder surgery were excluded. Results: Obesity was significantly associated (OR 2.10, p < 0.05) with aggressive PCa (Gleason Score 8 - 10). DMII was significantly associated to aggressive PCa but only in obese cases (OR 4.25). Carotid vascular disease (CVD) and coronary artery disease (CAD) were significantly linked to PCa in all cases versus controls (OR 1.88, p < 0.05). Conclusions: In our study, obesity, particularly in combination with DMII, was significantly associated with aggressive PCa. Moreover, a significant relation was found between vascular disease and PCa hormone-naive at initial diagnosis. The metabolic derangements associated to obesity and DMII may increase oxidative stress and cause a permanent pro-inflammatory state that predisposes to vascular disease and PCa.

Cite this paper

Francesco, S. and Tenaglia, R. (2014) Obesity, Diabetes Mellitus and Vascular Disease: A Complex Relationship with Prostate Cancer. Journal of Cancer Therapy, 5, 442-447. doi: 10.4236/jct.2014.55050.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Morote, J., Celma, A., Planas, J., Placer, J., Konstantinidis, C., Iztueta, I., de Torres, I.M., Oliván, M., Reventós, J. and Doll, A. (2013) Sedentarism and Overweight as Risk Factors for the Detection of Prostate Cancer and Its Aggressivenes. Actas Urol Esp.
[2] Parker, A.S., Thiel, D.D., Bergstralh, E., Carlson, R.E., Rangel, L.J., Joseph, R.W., Diehl, N. and Karnes, R.J. (2013) Obese Men Have More Advanced and More Aggressive Prostate Cancer at Time of Surgery than Non-Obese Men after Adjusting for Screening PSA Level and Age: Results from Two Independent Nested Case-Control Studies. Prostate Cancer Prostatic Disease, 16, 352-356. http://dx.doi.org/10.1038/pcan.2013.27
[3] Su, L.J., Arab, L., Steck, S.E., Fontham, E.T., Schroeder, J.C., Bensen, J.T. and Mohler, J.L. (2011) Obesity and Prostate Cancer Aggressiveness among African and Caucasian Americans in a Population-Based Study. Cancer Epidemiology Biomarkers Prevention, 20, 844-853.
http://dx.doi.org/10.1158/1055-9965.EPI-10-0684
[4] Jayachandran, J., Aronson, W.J., Terris, M.K., Presti Jr., J.C., Amling, C.L., Kane, C.J. and Freedland, S.J. (2010) Diabetes and Outcomes after Radical Prostatectomy: Are Results Affected by Obesity and Race? Results from the Shared Equal-Access Regional Cancer Hospital Database. Cancer Epidemiology Biomarkers Prevention, 19, 9-17. http://dx.doi.org/10.1158/1055-9965.EPI-09-0777
[5] Gallina, A., Karakiewicz, P.I., Hutterer, G.C., Chun, F.K., Briganti, A., Walz, J., Antebi, E., Shariat, S.F., Suardi, N., Graefen, M., Erbersdobler, A., Salonia, A., Rigatti, P., Huland, H. and Montorsi, F. (2007) Obesity Does Not Predispose to More Aggressive Prostate Cancer Either at Biopsy or Radical Prostatectomy in European Men. International Journal of Cancer, 121, 791-795.
http://dx.doi.org/10.1002/ijc.22730
[6] Wu, C., Aronson, W.J., Terris, M.K., Presti Jr., J.C., Kane, C.J., Amling, C.L. and Freedland, S.J. (2013) Diabetes Predicts Metastasis after Radical Prostatectomy in Obese Men: Results from the SEARCH Database. BJU International, 111, E310-E318. http://dx.doi.org/10.1111/j.1464-410X.2012.11687.x
[7] Margel, D., Urbach, D., Lipscombe, L.L., Bell, C.M., Kulkarni, G., Austin, P.C. and Fleshner, N. (2013) Association between Metformin Use and Risk of Prostate Cancer and Its Grade. Journal of National Cancer Institution, 105, 1123-1131.
[8] Hu, M., Xu, H., Bai, P., Jiang, H. and Ding, Q. (2014) Obesity Has Multifaceted Impact on Biochemical Recurrence of Prostate Cancer: A Dose-Response Meta-Analysis of 36,927 Patients. Medical Oncology, 31, 829. http://dx.doi.org/10.1007/s12032-013-0829-8
[9] Gallina, A., Karakiewicz, P.I., Hutterer, G.C., Chun, F.K., Briganti, A., Walz, J., Antebi, E., Shariat, S.F., Suardi, N., Graefen, M., Erbersdobler, A., Salonia, A., Rigatti, P., Huland, H. and Montorsi, F. (2007) Obesity Does Not Predispose to More Aggressive Prostate Cancer Either at Biopsy or Radical Prostatectomy in European Men. International Journal of Cancer, 121, 791-795.
http://dx.doi.org/10.1002/ijc.22730
[10] Turner, E.L., Lane, J.A., Donovan, J.L., Davis, M.J., Metcalfe, C., Neal, D.E., Hamdy, F.C. and Martin, R.M. (2011) Association of Diabetes Mellitus with Prostate Cancer: Nested Case-Control Study (Prostate Testing for Cancer and Treatment Study). International Journal of Cancer, 128, 440-446. http://dx.doi.org/10.1002/ijc.25360
[11] Satariano, W.A., Ragland, K.E. and Van Den Eeden, S.K. (1998) Cause of Death in Men Diagnosed with Prostate Carcinoma. Cancer, 83, 1180-1188. http://dx.doi.org/10.1002/(SICI)1097-0142 (19980915)83:6<1180::AID-CNCR18>3.0.CO;2-1
[12] Fouad, M.N., Mayo, C.P., Funkhouser, E.M., Hall, H.I., Urban, D.A. and Kiefe, C.I. (2004) Comorbidity Independently Predicted Death in Older Prostate Cancer Patients, More of Whom Died with than from Their Disease. Journal of Clinical Epidemiology, 57, 721-729.
http://dx.doi.org/10.1016/j.jclinepi.2003.11.009
[13] Groome, P.A., Rohland, S.L., Siemens, D.R., Brundage, M.D., Heaton, J. and Mackillop, W.J. (2011) Assessing the Impact of Comorbid Illnesses on Death within 10 Years in Prostate Cancer Treatment Candidates. Cancer, 117, 3943-3952. http://dx.doi.org/10.1002/cncr.25984
[14] Omalu, B.I., Hammers, J.L., Parwani, A.V., Balani, J., Shakir, A. and Ness, R.B. (2013) Niger Is There an Association between Coronary Atherosclerosis and Carcinoma of the Prostate in Men Aged 50 Years and Older? An Autopsy and Coroner Based Post-Mortem Study. Journal of Clinical Practice, 16, 45-48.
[15] Dreyer, L. and Olsen, J.H. (1999) Risk for Non-Smoking-Related Cancer in Atherosclerotic Patients. Cancer Epidemiological Biomarkers Prevention, 8, 915-918.
[16] Stamatiou, K.N., Alevizos, A.G., Mihas, K., Mariolis, A.D., Michalodimitrakis, E. and Sofras, F. (2007) Associations between Coronary Heart Disease, Obesity and Histological Prostate Cancer. International Urology and Nephrology, 39, 197-201. http://dx.doi.org/10.1007/s11255-006-9010-z
[17] Heron, M., Hoyert, D.L., Murphy, S.L., Xu, J., Kochanek, K.D. and Tejada-Vera, B. (2009) Deaths: Final Data for 2006. National Vital Statistics Reports, 57, 1-134.
[18] Thomas, J.A., Gerber, L., Banez, L.L., Moreira, D.M., Rittmaster, R.S., Andriole, G.L. and Freedland, S.J. (2012) Prostate Cancer Risk in Men with Baseline History of Coronary Artery Disease: Results from the REDUCE Study. Cancer Epidemiol Biomarkers Prevention, 21, 576-581.
http://dx.doi.org/10.1158/1055-9965.EPI-11-1017
[19] Cohen, D.H. and LeRoith, D. (2012) Obesity, Type 2 Diabetes, and Cancer: The Insulin and IGF Connection. Endocrine-Related Cancer, 19, F27-F45. http://dx.doi.org/10.1530/ERC-11-0374
[20] Ma, J., Li, H., Giovannucci, E., et al. (2008) Prediagnostic Body-Mass Index, Plasma C-Peptide Concentration, and Prostate Cancer-Specific Mortality in Men with Prostate Cancer: A Long-Term Survival Analysis. Lancet Oncology, 9, 1039-1047. http://dx.doi.org/10.1016/S1470-2045(08)70235-3
[21] Duman, B.S., Turkoglu, C., Gunay, D., Cagatay, P., Demiroglu, C. and Buyukdevrim, A.S. (2003) The Interrelationship between Insulin Secretion and Action in Type 2 Diabetes Mellitus with Different Degrees of Obesity: Evidence Supporting Central Obesity. Diabetes, Nutrition & Metabolism, 16, 243-250.
[22] Moreira, D.M., Anderson, T., Gerber, L., Thomas, J.A., Banez, L.L., McKeever, M.G., Hoyo, C., Grant, D., Jayachandran, J. and Freedland, S.J. (2011) The Association of Diabetes Mellitus and High-Grade Prostate Cancer in a Multiethnic Biopsy Series. Cancer Causes & Control, 22, 977-983.
http://dx.doi.org/10.1007/s10552-011-9770-3
[23] Xylinas, E., Ploussard, G., Durand, X., et al. (2011) Low Pretreatment Total Testosterone (<3 ng/mL) Predicts Extraprostatic Disease in Prostatectomy Specimens from Patients with Preoperative Localized Prostate Cancer. BJU International, 107, 1400-1403. http://dx.doi.org/10.1111/j.1464-410X.2010.09816.x
[24] Yamamoto, S., Yonese, J., Kawakami, S., Ohkubo, Y., Tatokoro, M., Komai, Y., Takeshita, H., Ishikawa, Y. and Fukui, I. (2007) Preoperative Serum Testosterone Level as an Independent Predictor of Treatment Failure Following Radical Prostatectomy. European Urology, 52, 696-701.
http://dx.doi.org/10.1016/j.eururo.2007.03.052
[25] Eltzschig, H.K. and Carmeliet, P. (2011) Hypoxia and Inflammation. New England Journal of Medicine, 364, 656-665.
[26] Jin, R.J., Lho, Y., Connelly, L., Wang, Y., Yu, X., Saint Jean, L., Case, T.C., Ellwood-Yen, K., Sawyers, C.L., Bhowmick, N.A., Blackwell, T.S., Yull, F.E. and Matusik, R.J. (2008) The Nuclear Factor-κB Pathway Controls the Progression of Prostate Cancer to Androgen-Independent Growth. Cancer Research, 68, 6762-6769. http://dx.doi.org/10.1158/0008-5472.CAN-08-0107
[27] Gorbachinsky, I., Akpinar, H. and Assimos, D.G. (2010) Metabolic Syndrome and Urologic Diseases. Reviews in Urology, 12, e157-e180.
[28] Omalu, B.I., Hammers, J.L., Parwani, A.V., Balani, J., Shakir, A. and Ness, R.B. (2013) Is there an Association Between Coronary Atherosclerosis and Carcinoma of the Prostate in Men Aged 50 Years and Older? An Autopsy and Coroner Based Post-Mortem Study. Nigerian Journal of Clinical Practice, 16, 45-48.
[29] Dreyer, L. and Olsen, J.H. (1999) Risk for Non-Smoking-Related Cancer in Atherosclerotic Patients. Cancer Epidemiology Biomarkers & Prevention, 8, 915-918.
[30] Stamatiou, K.N., Alevizos, A.G., Mihas, K., Mariolis, A.D., Michalodimitrakis, E. and Sofras, F. (2007) Associations between Coronary Heart Disease, Obesity and Histological Prostate Cancer. International Urology and Nephrology, 39, 197-201. http://dx.doi.org/10.1007/s11255-006-9010-z
[31] Heron, M., Hoyert, D.L., Murphy, S.L., Xu, J., Kochanek, K.D. and Tejada-Vera, B. (2009) Deaths: Final Data for 2006. National Vital Statistics Reports, 57, 1-134.
[32] Thomas, J.A., Gerber, L., Banez, L.L., Moreira, D.M., Rittmaster, R.S., Andriole, G.L. and Freedland, S.J. (2012) Prostate Cancer Risk in Men with Baseline History of Coronary Artery Disease: Results from the REDUCE Study. Cancer Epidemiology Biomarkers & Prevention, 21, 576-581.
http://dx.doi.org/10.1158/1055-9965.EPI-11-1017
[33] Robinson, D., Garmo, H., Lindahl, B., Van Hemelrijck, M., Adolfsson, J., Bratt, O., Holmberg, L. and Stattin, P. (2012) Ischemic Heart Disease and Stroke before and during Endocrine Treatment for Prostate Cancer in PCBaSe Sweden. International Journal of Cancer, 130, 478-487.
http://dx.doi.org/10.1002/ijc.26022
[34] Zoller, B., Ji, J., Sundquist, J. and Sundquist, K. (2012) Risk of Coronary Heart Disease in Patients with Cancer: A Nationwide Follow-Up Study from Sweden. European Journal of Cancer, 48, 121-128. http://dx.doi.org/10.1016/j.ejca.2011.09.015

  
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