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Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from Taxodium distichum Cones

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DOI: 10.4236/abc.2014.42015    2,879 Downloads   4,268 Views   Citations

ABSTRACT

Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from Taxodium distichum cones and their biological properties evaluated in vitro against six different biological screening targets. Taxodione showed potent activity against a number of different targets, and salvinolone and 14-deoxycoleon U showed remarkable inhibitory activities against prolyl oligopeptidase (POP) and 17α-hydroxylase/C17,20-lyase (CYP17), respectively. These three compounds also showed strong cytotoxic activities against HL60 and K562 human leukemia cells. The structure-activity relationships of these compounds have also been considered. The findings in this study could lead to enhanced pharmacological prospects for the natural abietane-type diterpenoids consisting in conifer cones.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Kusumoto, N. , Aburai, N. , Ashitani, T. , Takahashi, K. and Kimura, K. (2014) Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from Taxodium distichum Cones. Advances in Biological Chemistry, 4, 109-115. doi: 10.4236/abc.2014.42015.

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