Role of Topical Application of Growth Factors on Periodontal Repair


Reconstruction of lost or injured periodontal tissues in such a way that both the original structures and their function are completely restored. Restoring of lost periodontal tissues involves a creation of new attachment, including the formation of a new periodontal ligament with its fibers inserted in newly formed cementum and alveolar bone. The purpose of this research is to illustrate the biological actions of topical application of growth factors TGF-β1, VEGF on periodontal cells and tissues, which are involved in periodontal regeneration. Fifty-four male Albino rats were subjected for non surgical operation of distal sides of both lower anterior teeth, right side was considered as experimental site treated with 1 μm of VEGF, TGF-β1, while left side treated with 1 μm of normal saline as a control one. All the samples were studied histologically and histometry at three interval periods 3, 7, 14 days postoperatively. The results demonstrated that the mean value of amount of new bone and the mean of the length of junctional epithelia is showed to be higher in VEGF group, while the mean of periodontal ligament width and mean of rate of bone maturation are reported to be higher in combination group. High mean value for the width of cellular cementum is recorded in TGF group. Conclusion: The present study suggested that growth factors application in injured periodontium have a role in periodontal healing and VEGF illustrates to be the most powerful one.

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Al-Hijazi, A. and Al-Mahammadawy, A. (2014) Role of Topical Application of Growth Factors on Periodontal Repair. Natural Science, 6, 351-361. doi: 10.4236/ns.2014.65036.

Conflicts of Interest

The authors declare no conflicts of interest.


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