Angiosarcoma Thyroid: Case Report and Review of Literature

Aayush Mittal, Sunil Kumar, Yumlembem Brojendro Singh, Sunil Garg

Department of Otorhinolaryngology—Head & Neck Surgery, Hind Institute of Medical Sciences and Shekhar Hospital, Lucknow, India.
Department of Otorhinolaryngology—Head & Neck Surgery, Lady Hardinge Medical College, New Delhi, In-dia.

DOI: 10.4236/crcm.2014.33026                

Abstract

Objective: To describe a rare case of angiosarcoma thyroid in Indian subcontinent with its successful management. Case report: A 60-year-old male with swelling in neck for 20years with sudden increase in the size during last 3 months. Fine needle aspiration cytology suggested anaplastic carcinoma. The patient underwent total thyroidectomy with central and lateral neck dissection. On histopathology, the diagnosis of angiosarcoma was suspected. Immunohisto chemistry confirmed the diagnosis of angiosarcoma. Post-operative chemoradiation was given with no recurrence at 10 months of follow up. Conclusion: Though rare, angiosarcoma should be included as differential diagnosis in cases of long standing goiters with recent rapid increase in size. Immunohistochemistry is crucial for diagnosis and should be considered in these patients. Early and prompt diagnosis will help in providing curative treatment in such patients.

Keywords

Angiosarcoma; Thyroid

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Sniezek, J.C. and Holten, M. (2003) Rare Tumors of the Thyroid Gland. Otolaryngologic Clinics of North America, 36, 107-115.
[2]	Papotti, M., Arrondini, M., Tavaglione, V., Veltri, A. and Volante, M. (2008) Diagnostic Controversies in Vascular Proliferations of the Thyroid Gland. Endocrine Pathology, 19, 175-183. http://dx.doi.org/10.1007/s12022-008-9039-x
[3]	Isa, N.M., James, D.T., Pennisi, R. and Gough, I. (2009) Primary Angiosarcoma of the Thyroid Gland with Recurrence Diagnosed by Fine Needle Aspiration: A Case Report. Diagnostic Cytopathology, 37, 427-432. http://dx.doi.org/10.1002/dc.21065
[4]	Goh, S.G., Chuah, K.L., Goh, H.K. and Chen, Y.Y. (2003) Two Cases of Epithelioid Angiosarcoma Involving the Thyroid and a Brief Review of Non-Alpine Epithelioid Angiosarcoma of the Thyroid. Archives of Pathology & Laboratory Medicine, 127, 70-73.
[5]	Petronella, P. (2012) Primary Thyroid Angiosarcoma: An Unusual Localization. World Journal of Surgical Oncology, 10, 73. http://dx.doi.org/10.1186/1477-7819-10-73
[6]	Yilmazlar, T., Kirdak, T., Adim, S., Ozturk, E. and Yerci, O. (2005) A Case of Hemangiosarcoma in Thyroid with Severe Anemia Due to Bone Marrow Metastasis. Endocrine Journal, 52, 57-59. http://dx.doi.org/10.1507/endocrj.52.57
[7]	Astl, J., Duskova, J., Limanova, Z., Povysil, C. and Kuchynkova, Z. (2000) Hemangiosarcoma of the Thyroid Gland. A Case Report. Neuro Endocrinology Letters, 21, 213-216.
[8]	Hassan, I., et al. (2005) An Authentic Malignant Epithelioid Hemangioendothelioma of the Thyroid: A Case Report and Review of Literature. Thyroid, 12, 1377-1381. http://dx.doi.org/10.1089/thy.2005.15.1377
[9]	Maiorana, A., Collina, G., Cesinaro, A.M., Fano, R.A. and Eusebi, V. (1996) Angiomatoid Carcinoma of the Thyroid: Clinicopathological Analysis of Seven Cases from Non-Alpine Areas. Virchows Arch, 429, 131-137.
[10]	Ritter, J.H., Mills, S.E., Nappi, O. and Wick, M.R. (1995) Angiosarcoma-Like Neoplasms of Epithelial Organs: True Endothelial Tumors or Variants of Carcinoma? Seminars in Diagnostic Pathology, 12, 270-282.
[11]	De Lellis, Ronald, A.D.L., Ricardo, V.L., Philipp, U.H. and Charis, E. (2004) Tumours of Endocrine Organs. In: WHO Classification of Tumours, WHO, Geneva, 113-114.
[12]	Papotti, M., Volante, M., Negro, F., Eusebi, V. and Bussolati, G. (2000) Thyroglobulin mRNA Expression Helps to Distinguish Anaplastic Carcinoma from Angiosarcoma of the Thyroid. Virchows Arch, 437, 635-642. http://dx.doi.org/10.1007/s004280000308