Highly-Efficient Conversion of Primary Amides to Nitriles Using Indium(III) Triflate as the Catalyst

Abstract

Indium(III) triflate, a trivalent indium reagent, was shown to be a highly-efficient catalyst for the conversion of primary amides to the corresponding nitriles. The successful reactions required 5 mol% of indium(III) triflate, and toluene was proved to be the most suitable solvent. Various amides were subjected to this method, and each produced the corresponding nitriles in excellent yields.

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Mineno, T. , Shinada, M. , Watanabe, K. , Yoshimitsu, H. , Miyashita, H. and Kansui, H. (2014) Highly-Efficient Conversion of Primary Amides to Nitriles Using Indium(III) Triflate as the Catalyst. International Journal of Organic Chemistry, 4, 1-6. doi: 10.4236/ijoc.2014.41001.

Conflicts of Interest

The authors declare no conflicts of interest.

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