Ethanol Effects on Cortical EEG Correlation and Sexual Behavior in Male Rats

DOI: 10.4236/jbbs.2014.42012   PDF   HTML     3,657 Downloads   5,148 Views   Citations


Ethanol affects sexual behavior drastically, as much as its execution as well as its motivation. Ethanol is a central nervous system depressant and the prefrontal cortex (PFC) is one of the cortical areas most sensitive to its effects. This prefrontal area participates in the modulation of the cognitive control, and furthermore, by mean of connections with the parietal cortex (PC) plays an important role in the processing of sexually relevant stimuli. Considering that it has been reported that the ethanol affects the proper functioning of these cortical areas, particularly decreasing the degree of electroencephalographic (EEG) coupling or correlation between them, the aim of this study was to characterize the effect of a low dose of ethanol on EEG correlation, as well determining if this effect is associated with impaired sexual behavior in male rats. Nine male rats unilaterally implanted were simultaneously recorded the EEG from the PFC and PC to calculate the degree of EEG synchronization (correlation, r) between both cortices during the first 40 minutes post administration of 0.75 g/kg of ethanol. At the end of the EEG recording, the males were submitted to copulatory behavior with a receptive female rat. The ethanol administration was associated with a decreased intrahemispheric correlation of the fast bands between PFC and PC, as well as with an increased mount and intromission latency. This data showed that ethanol in moderate doses decreased the coupling degree between cortices. It is likely that this functional disconnection between the PFC and PC after the ethanol administration could be associated with the difficulty in discriminating incentive value of the sexual stimuli so that decreased the sexual motivation but not the performance of the copulatory parameters in the male rat.

Share and Cite:

M. Guevara, M. Hernández-González, M. Almanza-Sepúlveda, D. Abascal, P. Durán, C. Tapia and F. Torres, "Ethanol Effects on Cortical EEG Correlation and Sexual Behavior in Male Rats," Journal of Behavioral and Brain Science, Vol. 4 No. 2, 2014, pp. 92-98. doi: 10.4236/jbbs.2014.42012.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] R. L. Meisel and B. D. Sachs, “The Physiology of Male Sexual Behavior,” In: E. Knobil and J. Neill, Eds., The Physiology of Reproduction, Raven Press, New York, Vol. 2, 2nd Edition, 1994, pp. 3-96.
[2] S. Brailowsky, “Las Sustancias de los Sueños: Neuropsi-cofarmacología,” FCE-CONACYT, México, 1995.
[3] R. S. Feldman, J. S. Meyer and L. F. Quenzer, “Principles of Neuropsychopharmacology,” Sinauer Associates, Inc., Sunderland, 1997.
[4] T. M. Tzschentke, “The Medial Prefrontal Cortex as Part of the Brain Reward System,” Amino Acids, Vol. 19, No. 1, 2000, pp. 211-219.
[5] M. Hernánde-González and M. A. Guevara, “Participation of the Prefrontal Cortex in the Processing of Sexual and Maternal Incentives,” In: L. LoGrassso and G. Morretti, Eds., Prefrontal Cortex: Roles, Interventions and Traumas, Nova Science Publishers, 2009, pp. 115-157.
[6] D. Beracochea, T. P. Durkin and R. Jaffard, “On the Involvement of the Central Cholinergic System in Memory Deficits Induced by Long-Term Ethanol Consumption in Mice,” Pharmacology, Biochemistry and Behavior, Vol. 24, No. 3, 1986, pp. 519-524.
[7] D. B. Abrams and T. G. Wilson, “Ethanol, Sexual Arousal, and Self-Control,” Journal of Personality and Social Psychology, Vol. 45, No. 1, 1983, pp. 188-198.
[8] G. Farkas and R. C. Rosen, “The Effects of Ethanol on Male Sexual Arousal,” Journal of Studies on Alcohol, Vol. 37, 1976, pp. 265-272.
[9] N. Landa, J. Fernández-Montalvo and J. Tirapu, “Alteraciones Neuropsicológicas en el Alcoholismo: Una Revisión Sobre la Afectación de la Memoria y las Funciones Ejecutivas,” Adicciones, Vol. 16, No. 1, 2004, pp. 41-52.
[10] L. Roehrich and M. S. Goldman, “Experience-Dependent Neuropsychological Recovery and the Treatment of Alcoholism,” Journal of Consulting and Clinical Psychology, Vol. 61, No. 5, 1993, pp. 812-821.
[11] M. Hernández-González, A. Sanz-Martin, M. A. Guevara, C. Amezcua-Gutiérrez and M. Ruiz Díaz, “Alcohol Suppresses the Electroencephalographic Response to Visual Erotic Stimuli in Young Men,” Journal of Behavioral and Brain Science, Vol. 2, 2012, pp. 363-371.
[12] A. Sanz-Martin, M. Hernández-González, M. A. Guevara, G. Santana and G. Gumá-Díaz, “Efecto del Alcohol en la Organización Eléctrica Cerebral Durante una Tarea de Memoria de Trabajo Visuoespacial y su Relación con el Ciclo Menstrual,” Revista de Neurología, Vol. 58, No. 3, 2014, pp. 103-112.
[13] F. M. Ferraro and S. W. Kiefer, “Behavioral Analysis of Male Rat Sexual Motivation and Performance Following Acute Ethanol Treatment,” Pharmacology, Biochemistry and Behavior, Vol. 78, No. 3, 2004, pp. 427-433.
[14] K. Yoshimoto and W. J. McBride, “Regulation of Nucleus Accumbens Dopamine Release by the Dorsal Raphe Nucleus in the Rat,” Neurochemistry Research, Vol. 17, No. 5, 1992, pp. 401-407.
[15] K. Yoshimoto, K. Yayama, M. Ogata, A. Nishimura, T. Yoshida, S. Ueda, et al., “Possibility of 5-HT3 Receptor Involvement in Alcohol Dependence: A Microdialysis Study of Nucleus Accumbens Dopamine and Serotonin Release in Rats with Chronic Alcohol Consumption,” Alcoholism: Clinical and Experimental Research, Vol. 20, No. S9, 1996, pp. 311-319.
[16] M. S. Brodie, C. Pesold and S. B. Appel, “Ethanol Directly Excites Dopaminergic Ventral Tegmental Area Reward Neurons,” Alcoholism: Clinical and Experimental Research, Vol. 23, No. 11, 1999, pp. 1848-1852.
[17] G. Di Chiara, “Alcohol and Dopamine,” Alcohol Health & Research World, Vol. 21, No. 2, 1997, pp. 108-114.
[18] K. Kiianmaa, P. Hyytiä, H. H. Samson, J. A. Angel, L. Svensson, B. Söderpalm, et al., “New Neuronal Networks Involved in Ethanol Reinforcement,” Alcoholism: Clinical and Experimental Research, Vol. 27, No. 2, 2003, pp. 209-219.
[19] Y. Tizabi, R. L. Copeland Jr., V. A. Louis and R. E. Taylor, “Effects of Combined Systemic Alcohol and Central Nicotine Administration into Ventral Tegmental Area on Dopamine Release in the Nucleus Accumbens,” Alcoholism: Clinical and Experimental Research, Vol. 26, No. 3, 2002, pp. 304-399.
[20] F. Weiss and L. J. Porrino, “Behavioral Neurobiology of Alcohol Addiction: Recent Advances and Challenges,” Journal of Neuroscience, Vol. 22, No. 9, 2002, pp. 3332-3337.
[21] L. Yavich and J. Tiihonen, “Ethanol Modulates Evoked Dopamine Release in Mouse Nucleus Accumbens: Dependence on Social Stress and Dose,” European Journal of Pharmacology, Vol. 401, No. 3, 2000, pp. 365-373.
[22] C. J. Slawecki, “Altered EEG Responses to Ethanol in Adult Rats Exposed to Ethanol during Adolescence,” Alcoholism: Clinical and Experimental Research, Vol. 26, No. 2, 2002, pp. 246-254.
[23] M. Hernández-González, M. Martínez-Pelayo, M. Arteaga-Silva, H. Bonilla-Jaime and M. A. Guevara, “Ethanol Changes the Electroencephalographic Correlation of the Ventral Tegmental Area and Nucleus Accumbens, Components of the Mesoaccumbens System in Rats,” Pharmacology Biochemistry and Behavior, Vol. 92, No. 1, 2008, pp. 124-130.
[24] L. A. Mead and C. H. Vanderwolf, “Hippocampal Electrical Activity in the Female Rat: The Estrous Cycle, Copulation, Parturition, and Pup Retrieval,” Behavioral Brain Research, Vol. 50, No. 1-2, 1992, pp. 105-113.
[25] M. Hernández-González, M. A. Guevara, M. Cervantes, G. Moralí and M. Corsi-Cabrera, “Characteristic Frequency Bands of the Cortico-Frontal EEG during the Sexual Interaction of the Male Rat as a Result of Factorial Analysis,” Journal of Physiology-Paris, Vol. 92, No. 1, 1998, pp. 43-50.
[26] F. Lopes da Silva, “Neural Mechanisms Underlying Brain Waves: From Neural Membranes to Networks,” Electroencephalography and Clinical Neurophysiology, Vol. 79, No. 2, 1991, pp. 81-93.
[27] G. Paxinos and C. H. Watson, “The Rat Brain in Stereotaxic Coordinates,” Elsevier Academic Press, San Diego, 2005.
[28] M. A. Guevara, J. Ramos, M. Hernández-González, H. Madera and M. Corsi-Cabrera, “CAPTUSEN: A System for the Computerized Acquisition of EEG and Event-Related Potentials,” Mexican Journal of Psychology, Vol. 17, No. 1, 2000, pp. 77-88.
[29] A. Ågmo, A. Villalpando, Z. Picker and H. Fernández, “Lesions of the Medial Prefrontal Cortex and Sexual Behavior in the Male Rat,” Brain Research, Vol. 696, No. 1-2, 1995, pp. 177-186.
[30] M. Hernández-González, C. A. Prieto-Beracoechea, M. Arteaga-Silva and M. A. Guevara, “Different Functionality of the Medial and Orbital Prefrontal Cortex during a Sexually Motivated Task in Rats,” Physiology & Behavior, Vol. 90, No. 2-3, 2007, pp. 450-458.
[31] J. F. Lubar, T. J. Herrman, D. R. Moore and M. N. Shouse, “Effect of Septal and Frontal Ablations on Species Typical Behavior in the Rat,” Journal of Comparative and Physiological Psychology, Vol. 83, No. 2, 1973, pp. 260-270.
[32] A. Fernández-Guasti, I. Omana-Zapata, M. Luján and M. Condés-Lara, “Actions of Sciatic Nerve Ligature on Sexual Behavior of Sexually Experience and Inexperienced Male Rats: Effects of Frontal Pole Decortication,” Physiology and Behavior, Vol. 55, No. 3, 1994, pp. 577-581.
[33] A. Sanz-Martin, M. A. Guevara, C. Amezcua, G. Santana and M. Hernández-González, “Effects of Red Wine on the Electrical Activity and Functional Coupling between Prefrontal-Parietal Cortices in Young Men,” Appetite, Vol. 57, No. 1, 2011, pp. 84-93.
[34] E. Schwartz, P. Kielholz, L. Goldberg, U. Gilsdorf, M. Hofstetter, D. Ladewig, et al., “Alcohol-Induced Biphasic Background and Stimulus-Elicited EEG Changes in Relation to Blood Alcohol Levels,” International Journal of Clinical Pharmacology, Therapy and Toxicology, Vol. 19, No. 3, 1981, pp. 102-111.
[35] J. T. Coult, “Neural Correlates of Attention and Arousal from Electrophysiology, Functional Neuroimaging and Psychopharmacology,” Progress in Neurobiology, Vol. 55, No. 4, 1998, pp. 343-361.
[36] V. N. Murthy and E. E. Fetz, “Coherent 25- to 35-Hz Oscillations in the Sensorimotor Cortex of Awake Behaving Monkeys,” Proceedings of the National Academy of Sciences of the USA, Vol. 89, No. 12, 1992, pp. 5670-5674.

comments powered by Disqus

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.