In Vivo Dynamic Image Characterization of Brain Tumor Growth Using Singular Value Decomposition and Eigenvalues
Murad Shibli
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DOI: 10.4236/jbise.2011.43026   PDF    HTML     4,475 Downloads   8,830 Views   Citations

Abstract

This paper presents a dynamic image approach to characterize the growth of brain cancer invasion of tumor gliomas cells using singular value decomposi-tion (SVD) technique. Such a dynamic image is identi-fied by the white and grey matter displayed by mag-netic resonance (MR) images of the patient brain taken at different times. SVD components and prop-erties have been analyzed for different brain images. It is figured out that the growth of tumor cells is quantized by the SVD eigenvalues. Since SVD geo-metrically interprets an ellipsoid transformation, then the higher the eigenvalues, the more of tumor growth is. In vivo SVD dynamic imaging offers a more pre-dictive model to assess the tumor therapy than con-ventional technologies. Furthermore, an efficient dy-namic white-black indicator of the tumor growth rate is constructed based on the change in the diagonal eigenvalues matrices of two MR images taken at dif-ferent times. Finally, SVD image processing results are demonstrated to verify the effectiveness of the applied approach that can be implemented for each individual patient.

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Shibli, M. (2011) In Vivo Dynamic Image Characterization of Brain Tumor Growth Using Singular Value Decomposition and Eigenvalues. Journal of Biomedical Science and Engineering, 4, 187-195. doi: 10.4236/jbise.2011.43026.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Konukoglu, E., Clatz, O., Bondiau, P.Y., Sermesant, M., Delingette, H. and Ayache, N. (2007) Towards an identification of tumor growth parameters from time series of images. Medical Image Computing and Computer-Assisted Intervention – MICCAI 2007 Lecture Notes in Computer Science, 4791, 549-556.
[2] Nugroho, H.A., Ihtatho, D. and Nugroho, H. (2008) Contrast enhancement for liver tumor identification. The MIDAS Journal - Grand Challenge Liver Tumor Segmentation (MICCAI Workshop), 11 pages, private issue, July, Kitware Inc., USA, 2008.
[3] Ishizawa, T., Fukushima, N., Shibahara, J., Masuda, K., Tamura, S., Aoki, T., Hasegawa, K., Beck, Y., Fukayama, M. and Kokudo, N. (2009) Real-time identification of liver cancers by using indocyanine green fluorescent imaging. Cancer Journal, American Cancer Society.
[4] Chin, K.M., Wessler, B., Chew, P. and Lau, J. (2006) Genetic tests for cancer. Agency for Healthcare Research and Quality, USA.
[5] Villers, A., Puech, P., Leroy, X., Biserte, J., Fantoni, J.C. and Lemaitre, L. (2007) Dynamic contrast-enhanced MRI for preoperative identification of localised prostate cancer. European Association of Urology. European Urology Supplements, Elsevier B.V., Science Direct.
[6] Klema, V.C. and Laub, A.J. (1980) The singular value decomposition: its computation and some applications,” IEEE Transactions on Automatic Control, 25, 164-176.
[7] Ashino, R., Morimoto, A., Nagase, M. and Vaillancourt, R. (2003) Comparing multiresolution SVD with other methods for image compression. Proceedings of the 4th International ISAAC Congress, York University, Toronto, 11-16 August 2003, 457-470.
[8] Joro, R., L??peri, A.L., Soimakallio, S., J?rvenp??, R., Kuukasj?rvi, T., Toivonen, T., Saaristo, R. and Dastidar, P. (2008) Dynamic infrared imaging in identification of breast cancer tissue with combined image processing and frequency analysis. Journal of Medical Engineering & Technology, 32, 325-335. doi:10.1080/03091900701541240
[9] Clatz, O., Sermesant, M., Bondiau, P., Delingette, H., Warfield, S., Malandain, G. and Ayache, N. (2005) Realistic simulation of the 3D growth of brain tumors in MR images coupling diffusion with biomechanical deformation. IEEE Transactions on Medical Imaging, 24, 1334-1346.
[10] Konukoglu, E., Sermesant, M., Clatz, O., Peyrat, J.M., Delingette, H. and Ayache, N. (2007) A recursive anisotropic fast marching approach to reaction diffusion equation: application to tumor growth modeling. Information Processing in Medical Imaging, 20, 687-699.
[11] Warburg, O.H. (1969) The prime cause and prevention of cancer. The Second Revised Edition Published by Konrad Triltsch, Würzburg, Germany.
[12] Brewer, A.K. (1984) The high PH therapy for cancer, tests on mice and humans. Pharmacology Biochemistry & Behavior, 21, 15. doi:10.1016/0091-3057(84)90152-7
[13] Ralph W.M. (2004) Losing the war on cancer. Townsend Letter for Doctors & Patients.
[14] Kirschner, D. (2009) On the Global Dynamics of a Model for Tumor Immunotherapy. Mathematical Biosciences and Engineering, 6, 573-583.
[15] Ledzewicz, U. (2005) Optimal control for a system mo- delling tumor anti-angiogenesis. ACSE 05 Conference, CICC, Cairo, 19-21 December 2005, 147-152.
[16] Ghaffari, A. and Nasserifar, N. (2009) Mathematical modeling and lyapunov-based drug administration in cancer chemotherapy. Journal of Electrical & Electronic Engineering, 5, 151-158.

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