Antioxidants as effective remedies at hepatotoxic action of carbon tetrachloride

DOI: 10.4236/jbpc.2014.51001   PDF   HTML     3,165 Downloads   4,683 Views   Citations

Abstract

The liver, as the central metabolic organ, plays an important role in metabolism of carbohydrates, lipids and proteins. In the environment, there are many hepatotoxic xenobiotics. CCl4 is a free radical toxic for organelles of hepatocytes. The presented work was studying the character of ultrastructural changes in CCl4-intoxicated hepatocytes as well as the tissue after treatment by grape seed extract (GSE), α-tocopherol (α-T). As a result of cell bioremediation effect and reactions against corruptive factors, the liver has a high regeneration ability.

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Hovnanyan, K. , Mamikonyan, V. , Margaryan, A. , Sargsyan, K. , Hovnanyan, M. , Karagyozyan, M. and Karageuzyan, K. (2014) Antioxidants as effective remedies at hepatotoxic action of carbon tetrachloride. Journal of Biophysical Chemistry, 5, 1-4. doi: 10.4236/jbpc.2014.51001.

Conflicts of Interest

The authors declare no conflicts of interest.

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