Share This Article:

Polysaccharides as initiators of nucleic acid polymerization

Abstract Full-Text HTML Download Download as PDF (Size:357KB) PP. 20-25
DOI: 10.4236/ajmb.2014.41004    3,414 Downloads   6,508 Views   Citations

ABSTRACT

Quantum-chemical calculations and in vitro experiments have demonstrated that polysaccharides are able to adsorb mononucleotides due to the formation of hydrogen bonds. The subsequent dehydration of polysaccharide-nucleotide complexes in the physiologically acceptable temperature range results in the creation of “correct” DNA polymers that are “recognized” by the specific DNA-polymerases. DNA fragments abiogenically formed on polysaccharides vary in size and are characterized by a relatively “simple”, most probably, tandem structure. This research developed our previous concept of template-based polysaccharide synthesis with the participation of DNA tandem repeats (glycotranscription concept) making it possible to assume the existence of reverse glycotranscription in biological systems. Future research in the direction that we outlined experimentally may lead to a revolutionary approach in modern molecular biology—glycogenomics.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Zimnitskii, A. , Bashkatov, S. , Chemeris, A. , Yamidanov, R. and Urazbaev, V. (2014) Polysaccharides as initiators of nucleic acid polymerization. American Journal of Molecular Biology, 4, 20-25. doi: 10.4236/ajmb.2014.41004.

References

[1] Zimnitskii, A.N., Bashkatov, S.A. and Urazbaev, V.N. (2007) Interaction between nucleic acids and glycans: In silico and in vitro. Biophysics, 52, 282-287.
http://nanoderm.ru/img/userimg/statyi/magazine_biofizika_eng.pdf
http://dx.doi.org/10.1134/S0006350907030049
[2] Zimnitskii, A.N. (2012) Concept of template synthesis of proteoglycans. In: Desiree, N.K., Ed., The Complex World of Polysaccharides, InTech.
http://www.intechopen.com/books/the-complex-world-of-p
olysaccharides/concept-of-template-synthesis-of-proteoglycans
http://dx.doi.org/10.5772/48085
[3] Zimnitsky, A.N. and Bashkatov, S.A. (2006) Association of glycosaminoglycan biosynthesis with the nuclear and microsomal cell apparatuses. Molecular Biology, 40, 289-299.
http://nanoderm.ru/technology/nauchnye-stati-a_n_zimnicko-go/association_of_glucosaminoglycan_biosynthesis_with_the_nuclear_and_microsomal_cell_apparatuses
http://dx.doi.org/10.1134/S0026893306020117
[4] Singer, M. and Berg P. (1998) Genes and genomes. Mir, Moscow, 764 p.
[5] Orgel, L.E. (1998) The origin of life—A review of facts and speculations. Trends in Biochemical Sciences, 23, 491-495.
http://dx.doi.org/10.1016/S0968-0004(98)01300-0
[6] Osterman, L.A. (1981) Methods of investigating proteins and nucleic acids: Electrophoresis and ultracentrifugation. Nauka, Мoscow, 286 p.
[7] Gilyazetdinov, S.Y. and Zimnitskii, A.N. (1986) Composition of poly(А+)-RNA population in the roots of corn heterotic hybrids and their original strains. Physiology of Plant, 33, 769-777.
[8] Sterwart, J.J.P. (1989) Optimization of parameters for semiempirical methods. II. Applications. Journal of Computational Chemistry, 10, 221-261.
[9] Schmidt, M.W., Baldridge, K.K., Boatz, J.A., Elbert, S.T., Gordon, M.S., Jensen, J.H., Koseki, S., Matsunaga, N., Nguyen, K.A., Su, S.J., Windus, T.L., Dupuis, M., Montgomery, J.A. (1993) General atomic and molecular electronic structure system. Journal of Computational Chemistry, 14, 1347-1363.
http://dx.doi.org/10.1002/jcc.540141112
[10] Chemeris, A.V., Magdanov, E.G., Garafutdinov, R.R., Matniyazov, R.T., Baimiev, A.K. Bikbulatova, S.M., Gimalov, F.R. and Vakhitov, V.A. (2013) Some technological past, present and future of modern biology by 2030. Biomics, 5, 10-43.
http://biomics.ru/nomera/2013/54-nekotoroe-tehnologichesk
oe-proshloe-nastoyaschee-a-takzhe-buduschee-sovremennoy-biologii-k-2030-godu-chast-pervaya.html

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.