A New Heptamethine Cyanine-Based Near-Infrared Fluorescent Probe for Divalent Copper Ions with High Selectivity

Zhixiang Han, Qingqing Yang, Lihui Liang, Xiaobing Zhang

Hunan Provincial People’s Hospital, Changsha, China.
School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, China.
School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, China 3State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha, China.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha, China.

DOI: 10.4236/ampc.2013.38043                

Abstract

A new near-infrared fluorophore 2-(2-Aminoethyl) pyridine-tricarbocyanine (1) was rationally designed and synthe-sized as a fluorescent probe for detection of Cu²⁺ with high selectivity. The response of Probe 1 is based on the fluorescence quenching upon binding to Cu²⁺. The sensing performance of the proposed Cu²⁺-sensitive Probe 1 was then investigated. The probe can be applied to the quantification detection of Cu²⁺ with a linear concentration range covering from 4.8 × 10^-7 to 1.6 × 10^-4 mol/L and a detection limit of 9.3 × 10^-8 mol/L. The experimental results showed that the response of 1 to Cu²⁺ was independent of pH in medium condition (pH 6.0-8.0), and exhibited excellent selectivity towards Cu²⁺ over other common metal cations.

Keywords

Near-Infrared Dye; Fluorescent Probe; Cu²⁺ Ions

Conflicts of Interest

The authors declare no conflicts of interest.

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