Electrochemical Synthesis of Titanium Nano Particles at Carbon Paste Electrodes and Its Applications as an Electrochemical Sensor for the Determination of Acetaminophen in Paracetamol Tablets


Titania nano particles were synthesized at carbon paste electrode by cyclic voltammetry and then it was employed for the determination of acetaminophen in phosphate buffer at pH 7.4. Carbon paste electrode with titania nano particle displayed excellent electrochemically catalytic activities by shifting the oxidation potential of acetaminophen towards the negative side. The mass transfer process at electrochemical interface was diffusion controlled. Electrochemical techniques such as, electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization methods were used to measure the resistance of the electrodes. The resistance of the titanium electrode decreased in two orders when compared to the bare carbon paste electrode; the decrease in the resistance of the electrode and increase in the surface area of the electrode are responsible for the negative shifting of the oxidation potential of acetaminophen. The present method was applied to the determination of actetaminophen in paracetamol tablet, urine and blood sample by using standard addition method and the obtained results were satisfactory with a good recovery of 98%.

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K. Gururaj and B. Swamy, "Electrochemical Synthesis of Titanium Nano Particles at Carbon Paste Electrodes and Its Applications as an Electrochemical Sensor for the Determination of Acetaminophen in Paracetamol Tablets," Soft Nanoscience Letters, Vol. 3 No. 4A, 2013, pp. 20-22. doi: 10.4236/snl.2013.34A006.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] R. Sandulescu, S. Mirel and R. Oprean, “The Development of Spectrophotometric Andelectroanalytical Methods for Ascorbic Acid Andacetaminophen and Their Applications in the Analysis Ofeffervescent Dosage Forms,” Journal of Pharmaceutical and Biomedical Analysis, Vol. 23, No. 1, 2000, pp. 77-87. http://dx.doi.org/10.1016/S0731-7085(00)00277-6
[2] X. D. ShangGuan, H. F. Zhang and J. B. Zheng, “Electrochemical Behavior and Differential Pulse Voltammetric Determination of Paracetamol at a Carbon Ionic Liquid Electrode,” Analytical Bioanalytical Chemistry, Vol. 391, No. 3, 2008, pp. 1049-1055. http://dx.doi.org/10.1007/s00216-008-2096-7
[3] I. Noviandri and R. Rakhmana, “Carbon Paste Electrode Modified with Carbon Nanotubes and Poly(3-aminophenol) for Voltammetric Determination of Paracetamol,” International Journal of Electrochemical Science, Vol. 7, No. 5, 2012, pp. 4479-4487.
[4] C. Y. Li, G. Q. Zhan, Q. D. Yang and J. J. Lu, “Electrochemical Investigation of Acetaminophen with a Carbon Nano-Tube Composite Film Electrode,” Bullatin of Korean Chemical Society, Vol. 27, No. 11, 2006, pp. 1854-1860.
[5] O. Gilbert, B. E. Kumara Swamy, U. Chandra and B. S. Sherigara, “Simultaneous Detection of Dopamine and Ascorbic Acid Using Polyglycine Modified Carbon Paste Electrode: A Cyclic Voltammetric Study,” Journal of Electroanalytical Chemistry, Vol. 636. No. 1-2, 2009, pp. 80-85. http://dx.doi.org/10.1016/j.jelechem.2009.09.016
[6] F. N. Atta, A. Galal and S. M. Azab, “Electrochemical Determination of Paracetamol Using Gold Nanoparticles —Application in Tablets and Human Fluids,” International Journal of Electrochemical Science, Vol. 6, No. 10, 2011, pp. 5082-5096.

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