Phase Transfer Catalysis Improved Synthesis of 3,4-Dihydropyrimidinones

DOI: 10.4236/ijoc.2013.33A009   PDF   HTML     6,217 Downloads   12,684 Views   Citations


Various 3,4-dihydropyrimidinones can be prepared via Biginelli reaction in aqueous media by using quaternary ammonium salts of different alkyl groups (C4 and C8) and anions (Cl- and Br-) as catalysts. The use of quaternary ammonium salts along with longer alkyl chains increases the yield of the Biginelli reaction; however, bromide ammonium salts are less active than the chloride ones.

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H. Slimi, K. Saïd, Y. Moussaoui and R. Salem, "Phase Transfer Catalysis Improved Synthesis of 3,4-Dihydropyrimidinones," International Journal of Organic Chemistry, Vol. 3 No. 3A, 2013, pp. 96-100. doi: 10.4236/ijoc.2013.33A009.

Conflicts of Interest

The authors declare no conflicts of interest.


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