Human-Related Emotional Stimuli Can Cause a Hippocampal and Thalamic Over-Response in People with Unstable Personalities

Abstract

Hippocampus is crucial for the formation of emotional memory. We found the relationship between hippocampal responses to emotional stimuli and the mental stabilities of people in our preliminary study. In this study, we have also evaluated how the emotional stimuli would affect amygdala and thalamus in the brain, and how the personality stabilities could relate to the responses in the brain using functional magnetic resonance imaging (fMRI). We evaluated the subjects personality features with the Yatabe-Guilford Personality Test (Y-G test) and psychosomatic symptoms with the Cornell Medical Index (CMI). The subjects were categorized into the mentally stable group and the mentally unstable group according to the total scores of the Y-G test and the CMI. The brain functional responses under emotional stimuli were measured using fMRI. The region of interest (ROI) analysis was performed to abstract significant changes in order to compare responses among the different emotional stimuli. We conducted the regression analysis to abstract the relationship between the mean % signal change from fMRI and the personality stability. The fMRI results showed that the hippocampus, thalamus, and right amygdala activities under the human relationship stimuli increased with ascending value of mental instability. Our findings suggest that the memory process in the hippocampus and the threat alarm system in the thalamus under the human-related stimuli crucially influence the emotional reaction of mentally unstable people. These processes in the brain would affect the event that stresses on human relationships that often cause people to suffer from mental disorders.

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Y. Mizuno-Matsumoto, T. Hayashi, E. Okamoto, D. Miwa, T. Asakawa, A. Muramatsu, M. Kato and T. Murata, "Human-Related Emotional Stimuli Can Cause a Hippocampal and Thalamic Over-Response in People with Unstable Personalities," Journal of Behavioral and Brain Science, Vol. 3 No. 7, 2013, pp. 509-517. doi: 10.4236/jbbs.2013.37053.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Ministry of Health, Labour and Welfare, “Mental Health,” 2012.
http://www.mhlw.go.jp/kokoro/speciality/detail_depressive.html
[2] Ministry of Health, Labour and Welfare, “Comprehensive Survey of Living Conditions,” 2010.
http://www.mhlw.go.jp/toukei/list/20-21.html
[3] Ministry of Labour and Welfare, “Survey of State of Employees’ Health,” 2007.
http://www.mhlw.go.jp/toukei/list/49-19.html
[4] B. Roozendaal, B. S. McEwen and S. Chattarji, “Stress, Memory and the Amygdala,” Nature Reviews Neuroscience, Vol. 10, No. 6, 2009, pp. 423-433.
http://dx.doi.org/10.1038/nrn2651
[5] I. Ueno, “Psychological Assessment Handbook,” Nishimura-Shyoten, Tokyo, 2001.
[6] CMI, “A Brief History of the Cornell Medical Index (CMI) in Weill Cornell Medical Library,” 2012.
http://library.weill.cornell.edu/About/cornellmedindex.html
[7] Y. Mizuno-Matsumoto, T. Hayashi, E. Okamoto, T. Asakawa, K. Sawamura, R. Ishii, S. Ukai and K. Shinosaki, “Measurement of Personality Stability in Infants and Young Adults under Emotional Stimuli Using a Brain Functional Reaction Method,” International Journal of Intelligent Computing in Medical Sciences and Image Processing (IC-MED Journal), Vol. 4, No. 1-2, 2011, pp. 39-64.
[8] N. H. Kalin, S. E. Shelton, R. J. Davidson and A. E. Kelley, “The Primate Amygdala Mediates Acute Fear but Not the Behavioral and Physiological Components of Anxious Temperament,” The Journal of Neuroscience, Vol. 21, No. 6, 2001, pp. 2067-2074.
[9] H. Garavan, J. C. Pendergrass, T. J. Ross, E. A. Stein and R. Risinger, “Amygdala Response to both Positively and Negatively Valenced Stimuli,” NeuroReport, Vol. 12, No. 12, 2001, pp. 1-5.
http://dx.doi.org/10.1097/00001756-200108280-00036
[10] J. A. Kauer and R. C. Malenka, “Synaptic Plasticity and Addiction,” Nature Reviews Neuroscience, Vol. 8, No. 11, 2007, pp. 844-858. http://dx.doi.org/10.1038/nrn2234
[11] F. Dolcos, K. S. LaBar and R. Cabeza, “Remembering One Year Later: Role of the Amygdala and the Medial Temporal Lobe Memory System in Retrieving Emotional Memories,” Proceedings of the National Academy of Sciences, Vol. 102, No. 7, 2005, pp. 2626-2631.
http://dx.doi.org/10.1073/pnas.0409848102
[12] T. Kitamura, Y. Saitoh, N. Takashima, A. Murayama, Y. Niibori, H. Ageta, M. Sekiguchi, M. H. Sugiyama and K. Inokuchi, “Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory,” Cell, Vol. 139, No. 4, 2009, pp. 814-827.
http://dx.doi.org/10.1016/j.cell.2009.10.020
[13] D. R. Vago, A. Bevan and R. P. Kesner, “The Role of the Direct Perforant Path Input to the CA1 Subregion of the Dorsal Hippocampus in Memory Retention and Retrieval,” Hippocampus, Vol. 17, No. 11, 2007, pp. 977-987.
http://dx.doi.org/10.1002/hipo.20329
[14] C. Rocher, M. Spedding, C. Munoz and T. M. Jay, “Acute Stress-Induced Changes in Hippocampal/Prefrontal Circuits in Rats: Effects of Antidepressants,” Cerebral Cortex, Vol. 14, No. 2, 2004, pp. 224-229.
http://dx.doi.org/10.1093/cercor/bhg122
[15] J. D. Bremner, P. Randall, T. M. Scott, R. A. Bronen, J. P. Seibyl, S. M. Southwick, R. C. Delaney, G. McCarthy, D. S. Charney and R. B. Innis, “MRI-Based Measurement of Hippocampal Volume in Patients with Comat-Related Posttraumatic Stress Disorder,” Journal of the American Psychiatric Association, Vol. 152, No. 7, 1995, pp. 973-981.
[16] M. Vythilingam, C. Heim, J. Newport, A. H. Miller, E. Anderson, R. Bronen, M. Brummer, L. Staib, E. Vermetten, D. S. Charney, C. B. Nemeroff and J. D. Bremner, “Childhood Trauma Associated with Smaller Hippocampal Volume in Women with Major Depression,” Journal of the American Psychiatric Association, Vol. 159, No. 12, 2002, pp. 2072-2080.
http://dx.doi.org/10.1176/appi.ajp.159.12.2072
[17] J. Kinnison, S. Padmala, J. M. Choi and L. Pessoa, “Network Analysis Reveals Increased Integration during Emotional and Motivational Processing,” The Journal of Neuroscience, Vol. 32, No. 24, 2012, pp. 8361-8372.
http://dx.doi.org/10.1523/JNEUROSCI.0821-12.2012
[18] Y. Nakagawa and T. Shimogori, “Diversity of Thalamic Progenitor Cells and Postmitotic Neurons,” European Journal of Neuroscience, Vol. 35, No. 10, 2012, pp. 1554-1562. http://dx.doi.org/10.1111/j.1460-9568.2012.08089.x
[19] B. Zikopoulos and H. Barbas, “Pathways for Emotions and Attention Converge on the Thalamic Reticular Nucleus in Primates,” The Journal of Neuroscience, Vol. 32, No. 15, 2012, pp. 5338-5350.
http://dx.doi.org/10.1523/JNEUROSCI.4793-11.2012
[20] L. Nummenmaa, E. Glerean, M. Viinikainen, I. P. Jaakelainen, R. Hari and M. Sams, “Emotion Promote Social Interaction by Synchronizing Brain Activity across Individuals,” Proceedings of the National Academy of Sciences, Vol. 109, No. 24, 2012, pp. 9599-9604.
http://dx.doi.org/10.1073/pnas.1206095109
[21] C. Diener, C. Kuehner, W. Brusniak, B. Ubl, M. Wessa and H. Flor, “A Meta-Analysis of Neurofunctional Imaging Studies of Emotion and Cognition in Major Depression,” NeuroImage, Vol. 61, No. 3, 2012, pp. 677-685.
http://dx.doi.org/10.1016/j.neuroimage.2012.04.005
[22] T. Suslow, H. Kugel, H. Reber, J. Bauer, U. Dannlowski, A. Kersting, V. Arolt, W. Heindel, P. Ohrmann and B. Egloff, “Automatic Brain Response to Facial Emotion as a Function of Implicitly and Explicitly Measured Extraversion,” NeuroScience, Vol. 167, No. 1, 2010, pp. 111-123. http://dx.doi.org/10.1016/j.neuroscience.2010.01.038

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