Novel Synthetic Method for the Vilsmeier-Haack Reagent and Green Routes to Acid Chlorides, Alkyl Formates, and Alkyl Chlorides

DOI: 10.4236/ijoc.2013.33A001   PDF   HTML   XML   11,630 Downloads   16,978 Views   Citations


An environmentally benign and practical preparation method for the Vilsmeier-Haack reagent (VH) has been developed by using phthaloyl dichloride with DMF in toluene or 2-chlorotoluene. Phthalic anhydride as the byproduct was recovered in high yield by simple filtration. Some aromatic acids have been transformed into the corresponding acid chlorides in good yields by employing the isolated VH. Treatment of primary or secondary alcohols with VH gave alkyl formates or alkyl chlorides by depending on the reaction conditions.

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Y. Kimura and D. Matsuura, "Novel Synthetic Method for the Vilsmeier-Haack Reagent and Green Routes to Acid Chlorides, Alkyl Formates, and Alkyl Chlorides," International Journal of Organic Chemistry, Vol. 3 No. 3A, 2013, pp. 1-7. doi: 10.4236/ijoc.2013.33A001.

Conflicts of Interest

The authors declare no conflicts of interest.


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