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When the skin meets the bowel: About a case

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DOI: 10.4236/ojgas.2013.36052    2,709 Downloads   3,937 Views  

ABSTRACT

Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal region which may be complicated by extraintestinal manifestations, as cutaneous involvement. Immune dysregulation resulting in a lymphocyte mediated destructive process has been suggested as a possible pathogenetic link between gut and skin-related manifestations. The authors describe an atypical clinical aspect of lichen ruber planus in a patient affected by vitiligo, alopecia areata and ulcerative colitis.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Giulia, G. , Anna, C. , Antonio, D. , Corrado, R. , Antonio, Z. , Giuseppe, T. , Antonio, B. and Annamaria, O. (2013) When the skin meets the bowel: About a case. Open Journal of Gastroenterology, 3, 303-306. doi: 10.4236/ojgas.2013.36052.

References

[1] Huang, B.L., Chandra, S. and Shih, D.Q. (2012) Skin manifestations of inflammatory bowel disease. Frontiers in Physiology, 3, 1-13. http://dx.doi.org/10.3389/fphys.2012.00013
[2] Ganzetti, G., Campanati, A. and Offidani, A. (2012) Alopecia areata: A possible extraintestinal manifestation of Crohn’s disease. Journal of Crohn’s and Colitis, 6, 962-963. http://dx.doi.org/10.1016/j.crohns.2012.05.023
[3] Taieb, A. and Picardo, M. (2009) Vitiligo. New England Journal of Medicine, 360, 160-169. http://dx.doi.org/10.1056/NEJMcp0804388
[4] Lavanya, N., Jayanthi, P., Rao, U.K. and Ranganathan, K. (2011) Oral lichen planus: An update on pathogenesis and treatment. Journal of Oral and Maxillofacial Pathology, 15, 127-132. http://dx.doi.org/10.4103/0973-029X.84474
[5] Campanati, A., Brandozzi, G., Giangiacomi, M., Simonetti, O., Marconi, B. and Offidani, A.M. (2008) Lichen striatus in adults and pimecrolimus: Open, off-label clinical study. International Journal of Dermatology, 47, 732-736. http://dx.doi.org/10.1111/j.1365-4632.2008.03654.x
[6] Ghevariya, V., Singhal, S. and Anand, S. (2013) The skin: A mirror to the gut. International Journal of Colorectal Disease, 28, 889-913. http://dx.doi.org/10.1007/s00384-012-1637-x
[7] Van Wijk, F. and Cheroutre H. (2010) Mucosal T cells in gut homeostasis and inflammation. Expert Review of Clinical Immunology, 6, 559-566. http://dx.doi.org/10.1586/eci.10.34
[8] Xie, S., Ding, L., Xiong, Z. and Zhu, S. (2012) Implications of Th1 and Th17 cells in pathogenesis of oral lichen planus. Journal of Huazhong University of Science and Technology-Medical Sciences, 32, 451-457. http://dx.doi.org/10.1007/s11596-012-0078-7
[9] Kotobuki, Y., Tanemura, A., Yang, L., Itoi, S., et al. (2012) Dysregulation of melanocyte function by Th17related cytokines: Significance of Th17 cell infiltration in autoimmune vitiligo vulgaris. Pigment Cell & Melanoma Research, 25, 219-230. http://dx.doi.org/10.1111/j.1755-148X.2011.00945.x
[10] Kobayashi, T., Okamoto, S., Hisamatsu, T., et al. (2008) IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease. Gut, 57, 1682-1689. http://dx.doi.org/10.1136/gut.2007.135053
[11] Tembhre, M.K. and Sharma, V.K. (2013) T helper and regulatory T cell cytokines in the peripheral blood of active alopecia areata. British Journal of Dermatology, 169, 543-548. http://dx.doi.org/10.1111/bjd.12396
[12] Mann, E.R., McCarthy, N.E., Peake, S.T.C., et al. (2012) Skin-and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease. Clinical & Experimental Immunology, 170, 122-130. http://dx.doi.org/10.1111/j.1365-2249.2012.04649.x
[13] Tillack, C., Ehmann, L.M., Friedrich, M., et al. (2013) Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment. Gut.http://www.ncbi.nlm.nih.gov/pubmed/23468464
[14] Alghamdi, K.M., Khurrum, H., Taieb, A. and Ezzedine, K. (2012) Treatment of generalized vitiligo with antiTNF-α Agents. Journal of Drugs in Dermatology, 11, 534-539.
[15] O’Neill, I.D. and Scully, C. (2013) Biologics in oral medicine: Ulcerative disorders. Oral Diseases, 19, 37-45. http://dx.doi.org/10.1111/j.1601-0825.2012.01931.x

  
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