Ketoprofen/ethyl Cellulose Nanofibers Fabricated Using an Epoxy-coated Spinneret

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DOI: 10.4236/mnsms.2013.34B002    3,786 Downloads   5,783 Views   Citations


The present study investigates the preparation of sustained release drug-loaded nanofibers using a novel epoxy-coated spinneret. With ethyl cellulose (EC) and ketoprofen (KET) as the filament-forming matrix and the active pharmaceutical ingredient, Drug-loaded composite nanofibers are generated smoothly and continuously with few user interventions. Field-emission scanning electron microscopic observations demonstrated that the composite nanofibers prepared using the epoxy-coated spinneret have better quality than those from a traditional stainless steel spinneret in terms of diameter and its distribution. Both of the composite nanofibers are in essential a molecular solid dispersion of EC and KET based on the hydrogen bonding between them, as verified by XRD and ATR-FTIR results. In vitro dissolution tests show that the nanofibers resulted from the new spinneret provide a finer sustained KET release profile than their counter-parts. Epoxy-coated spinneret is a useful tool to facilitate the electrospinning process through the prevention of clogging for generating high quality nanofibers.

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X. Li, D. Yu, C. Fu, R. Wang and X. Wang, "Ketoprofen/ethyl Cellulose Nanofibers Fabricated Using an Epoxy-coated Spinneret," Modeling and Numerical Simulation of Material Science, Vol. 3 No. 4B, 2013, pp. 6-10. doi: 10.4236/mnsms.2013.34B002.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] D. G. Yu, L. M. Zhu, K. White and C. Branford-White, “Electrospun Nanofiber-based Drug Delivery Systems,” Health, Vol. 1, No. 2, 2009, pp. 67-75. doi:10.4236/health.2009.12012
[2] A. K. Moghe and B. S. Gupta, “Co‐axial Electrospinning for Nanofiber Structures: Preparation and Applications,” Polymer Review, Vol. 48, No. 2, 2008, pp. 353‐377. doi:10.1080/15583720802022257
[3] D. G. Yu, J. H. Yu, L. Chen, G. R. Williams and X. Wang, “Modified Coaxial Electrospinning for the Preparation of High-quality Ketoprofen-loaded Cellulose Acetate Nanofibers,” Carbohydrate Polymers, Vol. 90, No. 2, 2102, pp.1016-1023. doi: 10.1016/j.carbpol.2012.06.036
[4] D.G. Yu, X. Wang, X. Y. Li, W. Chian, Y. Li and Y. Z. Liao, “Electrospun Biphasic Drug Release Polyvinylpyrrolidone/ ethyl Cellulose Core/sheath Nanofibers,” Acta Biomaterialia, Vol. 9, No. 3, 2013, pp. 5665-5672. doi: 10.1016/j.actbio.2012.10.021
[5] D. G. Yu, X. Y. Li, X. Wang, W. Chian, Y. Z. Liao and Y. Li, “Zero-order Drug Release Cellulose Acetate Nanofibers Prepared Using Coaxial Electrospinning,” Cellulose, Vol. 20, No. 1, 2013, pp. 379-389. doi: 10.1007/s10570-012-9824-z
[6] D. G. Yu, W. Chian, X. Wang, X. Y. Li, Y. Li and Y. Z. Liao, “Linear Drug Release Membrane Prepared by a Modified Coaxial Electrospinning Process,” Journal of Membrane Sciences, Vol. 428, No. 3, 2013, pp. 150-156. doi: 10.1016/j.memsci.2012.09.062
[7] D. G. Yu, C. Branford-White, S. W. A. Bligh, K. White, N. P. Chatterton and L. M. Zhu, “Improving Polymer Nanofiber Quality Using a Modified Coaxial Electrospinning Process,” Macromolecular Rapid Communications, Vol. 32, No. 9-10, 2011, pp. 744-750. doi: 10.1002/marc.201100049
[8] D. G. Yu, L. M. Zhu, C. Branford-White, S. W. A. Bligh and K. White, “Coaxial Electrospinning with Organic Solvent for Controlling the Self-assembled Nanoparticle size,” Chemical Communications, Vol. 47, No. 4, 2011, pp. 1216-1218. doi: 10.1039/c0cc03521a
[9] D. G. Yu, C. Branford-White, N. P. Chatterton, K. White, L. M. Zhu, X. X. Shen and W. Nie, “Electrospinning of Concentrated Polymer Solutions,” Macromolecules, Vol. 43, No. 24, 2010, pp. 10743-10746. doi: 10.1021/ma1024363
[10] Z. Liu, D. D. Sun and P. Guo, “An Efficient Bicomponent TiO2/SnO2 Nanofiber Photocatalyst Fabricated by Electrospinning with a Side-by-side Dual Spinneret Method,” Nano Letters, Vol. 7, No. 3, 2007, pp. 1081-1085. doi: 10.1021/nl061898e
[11] T. Lin, H. Wang and X. Wang, “Self-Crimping bicomponent nanofibers electrospun from polyacrylonitrile and elastomeric polyure-thane,” Advanced Materials, Vol.17, No.7, 2005, pp. 2699–2703. doi: 10.1002/adma
[12] M. C. George and P. V. Braun, “Multicompartmental Materials by Electrohydrodynamic Cojetting,” Angewandte Chemie International Edition, Vol. 48, No. 8, 2009, pp. 8606- 8609. doi: 10.1002/anie.200904089
[13] L. Y. Huang, D. G. Yu, C. Branford-White and L. M. Zhu, “Sustained Release of Ethyl Cellulose Micro-particulate Drug Delivery Systems Prepared Using Electrospraying,” Journal of Materials Science, Vol.47, No. 3, 2012, pp. 1372-1377. doi: 10.1007/s10853-011-5913-x
[14] L. Y. Huang, C. Branford-White, X. X. Shen, D. G. Yu and L. M. Zhu, “Time-engineeringed Biphasic Drug Release by Electrospun Nanofiber Meshes,” International Journal of Pharmaceutics, Vol. 436, No. 1-2, 2012, pp. 88-96. doi: 10.1016/j.ijpharm.2012.06.058
[15] N. A. Peppas, “Analysis of Fickian and Non-Fickian Drug Release from Polymers,” Pharmaceutica Acta Helvetiae, Vol. 60, No. 1, 1985, pp. 110-111.

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