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Ketoprofen/ethyl Cellulose Nanofibers Fabricated Using an Epoxy-coated Spinneret

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DOI: 10.4236/mnsms.2013.34B002    3,740 Downloads   5,711 Views   Citations

ABSTRACT

The present study investigates the preparation of sustained release drug-loaded nanofibers using a novel epoxy-coated spinneret. With ethyl cellulose (EC) and ketoprofen (KET) as the filament-forming matrix and the active pharmaceutical ingredient, Drug-loaded composite nanofibers are generated smoothly and continuously with few user interventions. Field-emission scanning electron microscopic observations demonstrated that the composite nanofibers prepared using the epoxy-coated spinneret have better quality than those from a traditional stainless steel spinneret in terms of diameter and its distribution. Both of the composite nanofibers are in essential a molecular solid dispersion of EC and KET based on the hydrogen bonding between them, as verified by XRD and ATR-FTIR results. In vitro dissolution tests show that the nanofibers resulted from the new spinneret provide a finer sustained KET release profile than their counter-parts. Epoxy-coated spinneret is a useful tool to facilitate the electrospinning process through the prevention of clogging for generating high quality nanofibers.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

X. Li, D. Yu, C. Fu, R. Wang and X. Wang, "Ketoprofen/ethyl Cellulose Nanofibers Fabricated Using an Epoxy-coated Spinneret," Modeling and Numerical Simulation of Material Science, Vol. 3 No. 4B, 2013, pp. 6-10. doi: 10.4236/mnsms.2013.34B002.

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