Neural Substrates of Forward and Backward Associative Priming: A Functional MRI Study

Sarah Terrien, Fabien Gierski, Stéphanie Caillies, Véronique Baltazart, Christophe Portefaix, Laurent Pierot, Chrystel Besche-Richard

1Université de Reims Champagne-Ardenne, Laboratoire Cognition, Santé, Socialisation C2S EA 6291, Reims, France 2Institut Universitaire de France, Paris, France.
1Université de Reims Champagne-Ardenne, Laboratoire Cognition, Santé, Socialisation C2S EA 6291, Reims, France 2Service de Psychiatrie des Adultes, H?pital Robert Debré, CHU de Reims, Reims, France.
1Université de Reims Champagne-Ardenne, Laboratoire Cognition, Santé, Socialisation C2S EA 6291, Reims, France 2Service de Psychiatrie des Adultes, H?pital Robert Debré, CHU de Reims, Reims, France 3P?le d’Imagerie Médicale, H?pital Maison-Blanche, CHU de Reims, Reims, France.
P?le d’Imagerie Médicale, H?pital Maison-Blanche, CHU de Reims, Reims, France.
Université de Reims Champagne-Ardenne, Laboratoire Cognition, Santé, Socialisation C2S EA 6291, Reims, France.

DOI: 10.4236/psych.2013.410A007                

Abstract

Forward associative priming results of an association moves from the prime to the target whereas backward associative priming results of an association from the target to the prime (Koivisto, 1998). Little is known about this dissociation of process and the associated cerebral substrates. Fourteen healthy participants were included in this study. The task consisted in a lexical decision task using an fMRI-adapted semantic priming paradigm. Contrasts between forward related and forward unrelated conditions showed activation in the left temporal gyrus, left inferior prefrontal cortex, fusiform gyrus and occipital regions and cerebellum. Investigation of the different patterns of activation between forward and backward priming shows significant results: during the contrast between the forward priming effect and the backward priming effect, we observe a deactivation of BOLD response in temporal and frontal areas, which may reflect the post-lexical integration process. So, areas responsible for language and for decoding spelling seem not to be involved in the backward process. An adaptation of this research in event-related brain potentials is underway to better explore the temporality of post-lexical process.

Keywords

Semantic Memory; Forward and Backward Priming; fMRI; Left Superior Temporal Gyrus; Post-Lexical Integration

Conflicts of Interest

The authors declare no conflicts of interest.

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