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6-Azido-Galactosyl Imidate as a Building Block for Preparation of 1-(4-Aminobutyl)-, Di-, Tri- and Tetra-Saccharides

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DOI: 10.4236/ojmc.2013.33010    4,202 Downloads   6,577 Views   Citations

ABSTRACT

6-azidogalactosyl imidate has been used as a donor to generate 1-(4-aminobutyl)-6-aminogalactose, 6-aminothiotolyl- glycosides of disaccharide, trisaccharide and tetrasaccharide that incorporates 6-azido group and 1-(4-tolyl)thio group. Trisaccharide and tetrasaccharide were obtained from lactosyl-based acceptor. The anomeric 1-(4-tolyl)thio group could be used to conjugate with sphingosine analogs to provide the alpha-Gal Sph analogs for library extension from the azido group.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

K. Lin, L. Chiang, C. Pan, H. Huang, Y. Su, S. Chen, Y. Huang and C. Yu, "6-Azido-Galactosyl Imidate as a Building Block for Preparation of 1-(4-Aminobutyl)-, Di-, Tri- and Tetra-Saccharides," Open Journal of Medicinal Chemistry, Vol. 3 No. 3, 2013, pp. 74-86. doi: 10.4236/ojmc.2013.33010.

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