Recovery of nigrostriatal dopaminergic system insufficiency by allotransplantation of embryonic brain tissue

DOI: 10.4236/wjns.2013.34032   PDF   HTML   XML   3,417 Downloads   5,039 Views   Citations


In an experiment in rats with electrolytic lesion of the compact part of substantia nigra (SN) and after allotransplantation of the embryonic tissue of SN in the caudate nucleus the features of movement and emotional behavior in the Open Field Test (OFT), the rotation movements caused by an administration of amphetamine, a content of catecholamines in the caudate nucleus, hypothalamus and blood plasma have been investigated. It is shown that the electrolytic lesion causes violations of the statokinetic reflexes, the horizontal and the vertical movement activity, enhances the rotatory behavior, slow the orienttate-searching and the emotional reactions that combined with disbalance in dopamine-and noradrenalinetransmitter systems functioning. Allotransplantation of the embryonic dofaminsynthesizing brain tissue contributes to the restoration of movement activeity and its specific neurotransmitter ensuring. 

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Berchenko, O. and Usmentseva, Y. (2013) Recovery of nigrostriatal dopaminergic system insufficiency by allotransplantation of embryonic brain tissue. World Journal of Neuroscience, 3, 240-245. doi: 10.4236/wjns.2013.34032.

Conflicts of Interest

The authors declare no conflicts of interest.


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