Mammary Analogue Secretory Carcinoma of the Soft Palate: A Report of Two Cases


Mammary analogue secretory carcinoma (MASC) is a recently identified salivary tumor that shares morphological features of secretory carcinoma of the breast, salivary acinic cell carcinoma, low grade cystadenocarcinoma and mucoepidermoid carcinoma. To date, a majority of cases have been reported in the major salivary glands with very few seen in the palate. We present 2 single institution cases of MASC of the soft palate to help further characterize this novel tumor.

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D. Cooper, B. Burkey, D. Chute and J. Scharpf, "Mammary Analogue Secretory Carcinoma of the Soft Palate: A Report of Two Cases," International Journal of Otolaryngology and Head & Neck Surgery, Vol. 2 No. 5, 2013, pp. 174-178. doi: 10.4236/ijohns.2013.25037.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] D. M. Parkin, J. Ferlay, M. P. Curado, et al., “Fifty Years of Cancer Incidence: CI5 I-IX,” International Journal of Cancer, Vol. 127, No. 12, 2010, pp. 2918-2927. doi:10.1002/ijc.25517
[2] L. A. G. Ries, B. F. Hankey, B. A. Miller, et al., “Cancer Statistics Review 1973-88,” National Cancer Institute, Bethesda, 1991.
[3] C. Tognon, S. R. Knezevich, D. Huntsman, et al., “Expression of the ETV6-NTRK3 Gene Fusion as a Primary Event in Human Secretory Breast Carcinoma,” Cancer Cell, Vol. 2, No. 5, 2002, pp. 367-376. doi:10.1016/S1535-6108(02)00180-0
[4] S. I. Chiosea, et al., “The Profile of Acinic Cell Carcinoma after Recognition of Mammary Analog Secretory Carcinoma,” American Journal of Surgical Pathology, Vol. 36, No. 3, 2012, pp. 343-350. doi:10.1097/PAS.0b013e318242a5b0
[5] A. Skalova, T. Vanecek, R. Sima, et al., “Mammary Analogue Secretory Carcinoma of Salivary Glands, Containing the ETV6-NTRK3 Fusion Gene: A Hitherto Undescribed Salivary Gland Tumor Entity,” American Journal of Surgical Pathology, Vol. 34, No. 5, 2010, pp. 599-608. doi:10.1097/PAS.0b013e3181d9efcc
[6] F. J. Kratochvil 3rd, J. C. Stewart and S. R. Moore, “Mammary Analog Secretory Carcinoma of Salivary Glands: A Report of 2 Cases in the Lips,” Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 114, No. 5, 2012, pp. 630-635. doi:10.1016/j.oooo.2012.07.480
[7] S. I. Chiosea, C. Griffith, A. Assaad and R. R. Seethala, “Clinicopathological Characterization of Mammary Analogue Secretory Carcinoma of Salivary Glands,” Histopathology, Vol. 61, No. 3, 2012, pp. 387-394. doi:10.1111/j.1365-2559.2012.04232.x
[8] A. Fehr, T. Loning and G. Stenman, “Mammary Analogue Secretory Carcinoma of the Salivary Glands with ETV6-NTRK3 Gene Fusion,” American Journal of Surgical Pathology, Vol. 35, No. 10, 2011, pp. 1600-1602. doi:10.1097/PAS.0b013e31822832c7
[9] F. Petersson, D. Lian, Y. P. Chau and B. Yan, “Mammary Analogue Secretory Carcinoma: The First Submandibular Case Reported Including Findings on Fine Needle Aspiration Cytology,” Head and Neck Pathology, Vol. 6, No. 1, 2012, pp. 135-139. doi:10.1007/s12105-011-0283-x
[10] L. Pisharodi, “Mammary Analog Secretory Carcinoma of Salivary Gland: Cytologic Diagnosis and Differential Diagnosis of an Unreported Entity,” Diagnostic Cytopathology, Vol. 41, No. 3, 2012, pp. 239-243. doi:10.1002/dc.21766
[11] S. Ito, E. Ishida, A. Skalova, K. Matsuura, H. Kumamoto and I. Sato, “Case Report of Mammary Analog Secretory Carcinoma of the Parotid Gland,” Pathology International, Vol. 62, No. 2, 2012, pp. 149-152. doi:10.1111/j.1440-1827.2011.02759.x
[12] J. C. Rastatter, K. R. Jatana, L. J. Jennings and H. MelinAldana, “Mammary Analogue Secretory Carcinoma of the Parotid Gland in a Pediatric Patient, Otolaryngology —Head and Neck Surgery, Vol. 146, No. 3, 2012, pp. 514-515. doi:10.1177/0194599811419044
[13] S. D. Vincent, H. L. Hammond and M. W. Finkelstein, “Clinical and Therapeutic Features of Polymorphous LowGrade Adenocarcinoma,” Oral Surgery, Oral Medicine, Oral Pathology, Vol. 77, No. 1, 1994, pp. 41-47. doi:10.1016/S0030-4220(06)80105-2
[14] R. González-García, F. J. Rodríguez-Campo, M. F. Munoz-Guerra, S. H. Nam-Cha, J. Sastre-Pérez and L. Naval-Gías, “Polymorphous Low-Grade Adenocarcinoma of the Palate: Report of Cases,” Auris, Nasus, Larynx, Vol. 32, No. 3, 2005, p. 275. doi:10.1016/j.anl.2005.03.019
[15] J. T. Castle, L. D. Thompson, R. A. Frommelt, B. M. Wenig and H. P. Kessler, “Polymorphous Low Grade Adenocarcinoma,” Cancer, Vol. 86, No. 2, 1999, pp. 207-219. doi:10.1002/(SICI)1097-0142(19990715)86:2<207::AID-CNCR4>3.0.CO;2-Q
[16] I. A. El-Naaj, Y. Leiser, A. Wolff and M. Peled, “Polymorphous Low Grade Adenocarcinoma: Case Series and Review of Surgical Management,” Journal of Oral and Maxillofacial Surgery, Vol. 69, No. 7, 2011, pp. 1967-1972. doi:10.1016/j.joms.2010.10.010
[17] M. Brandwein-Gensler and D. R. Gnepp, “Low-Grade Cribriform Cystadenocarcinoma,” World Health Organization Classification of Tumours, Pathology & Genetics, Head and Neck Tumours, 2005.
[18] L. Wang, Y. Liu, X. Lin, D. Zhang, Q. Li, X. Qiu and E. H. Wang, “Low-Grade Cribriform Cystadenocarcinoma of Salivary Glands: Report of Two Cases and Review of the Literature,” Diagnostic Pathology, Vol. 8, No. 1, 2013, pp. 1-6. doi:10.1186/1746-1596-8-28

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