Pectin-Based Biodegradable Hydrogels with Potential Biomedical Applications as Drug Delivery Systems

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DOI: 10.4236/jbnb.2011.21005   PDF   HTML     9,222 Downloads   14,705 Views   Citations

Abstract

In this work, synthesis and swelling behavior of a superabsorbent hydrogel based on Pectin (Pc) and polyacrylonitrile (PAN) were investigated. A mechanism for hydrogel formation was proposed and the structure of the product was es-tablished using FTIR spectroscopy. The Pc-poly (sodium acrylate-co-acrylamide) hydrogel exhibited a pH-responsive swelling-deswelling behavior at pH’s 2 and 8. This on-off switching behavior provides the hydrogel with the potential to control delivery of bioactive agents. Release profiles of ibuprofen (IBU), a poor water-soluble drug, from the hydro-gels were studied under both simulated gastric and intestinal pH conditions.

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M. Sadeghi, "Pectin-Based Biodegradable Hydrogels with Potential Biomedical Applications as Drug Delivery Systems," Journal of Biomaterials and Nanobiotechnology, Vol. 2 No. 1, 2011, pp. 36-40. doi: 10.4236/jbnb.2011.21005.

Conflicts of Interest

The authors declare no conflicts of interest.

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