Convenient Cleavage Reaction of 1-Acylhydantoin to Amide


A cleavage reaction of 1-acylhydantoin by an amine in tetrahydrofuran at elevated temperature provided the corre-sponding amide and hydantoin in high yield. It was found that the addition of diethylaluminum chloride accelerated the cleavage reaction rate. The amide yield depended on the steric hindrance of the amine.

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J. Yamaguchi, K. Abe and T. Narushima, "Convenient Cleavage Reaction of 1-Acylhydantoin to Amide," International Journal of Organic Chemistry, Vol. 3 No. 3, 2013, pp. 194-197. doi: 10.4236/ijoc.2013.33025.

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The authors declare no conflicts of interest.


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