A rare cause for gestational trophoblastic neoplasia: Placental site trophoblastic tumor


Placental site trophoblastic tumor is a rare sub-group of gestational trophoblastic neoplasia. There is a wide clinical spectrum of presentation and behaviour ranging from a benign condition to an aggressive disease with a fatal outcome. We report a case of placental site trophoblastic tumor in 23-year-old women with irregular vaginal bleeding during postpartum lactation period. In addition to persistent low level β-hCG titers, ultrasound examination revealed a suspicious low-echoic area in the myometrium consistent with gestational trophoblastic disease. After histopathological examination of the specimen achieved by ultrasound-guided dilatation and curettage of the uterus, the placental site trophoblastic tumor diagnosis was made and subsequently total abdominal hysterectomy was performed. The patient had an uneventful recovery, and no recurrence was detected for 40 months in the follow-up period.

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Ulker, V. , Akyol, A. , Gedikbasi, A. , Numanoglu, C. , Demircivi, E. and Tuzlali, H. (2013) A rare cause for gestational trophoblastic neoplasia: Placental site trophoblastic tumor. Open Journal of Obstetrics and Gynecology, 3, 451-453. doi: 10.4236/ojog.2013.36084.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Kohorn, E.I. (2009) World-wide results of therapy for gestational trophoblastic disease. Gynecologic Oncology, 112, 85.
[2] Scully, R.E. and Young, R.H. (1981) Trophoblastic pseudotumor: A reappraisal. American Journal of Surgical Pathology, 5, 75-76. doi:10.1097/00000478-198101000-00010
[3] Kim, S.J. (2003) Placental site trophoblastic tumour. Best Practice & Research Clinical Obstetrics & Gynaecology, 17, 969-984. doi:10.1016/S1521-6934(03)00095-6
[4] Papadopoulos, A.J., Foskett, M., Seckl, M.J., McNeish, I., Paradinas, F.J., Rees, H. and Newlands, E.S. (2002) Twenty-five years’ clinical experience with placental site trophoblastic tumors. The Journal of Reproductive Medicine, 47, 460-464.
[5] Chang, Y.L., Chang, T.C., Hsueh, S., Huang, K.G., Wang, P.N., Liu, H.P. and Soong, Y.K. (1999) Prognostic factors and treatment for placental site trophoblastic tumorreport of 3 cases and analysis of 88 cases. Gynecologic Oncology, 73, 216-222. doi:10.1006/gyno.1999.5344
[6] Schmid, P., Nagai, Y., Agarwal, R., Hancock, B., Savage, P.M., Sebire, N.J., Lindsay, I., Wells, M., Fisher, R.A., Short, D., Newlands, E.S., Wischnewsky, M.B. and Seckl, M.J. (2009) Prognostic markers and long-term outcome of placental-site trophoblastic tumours: A retrospective observational study. The Lancet, 374, 48-55. doi:10.1016/S0140-6736(09)60618-8
[7] Baergen, R.N., Rutgers, J.L., Young, R.H., Osann, K. and Scully, R.E. (2006) Placental site trophoblastic tumor: A study of 55 cases and review of the literature emphasizing factors of prognostic significance. Gynecologic Oncology, 100, 511-520.
[8] Palmieri, C., Fisher, R.A., Sebire, N.J., Smith, J.R. and Newlands, E.S. (2005) Placental-site trophoblastic tumour: An unusual presentation with bilateral ovarian involvement. The Lancet Oncology, 6, 59-61.
[9] Feltmate, C.M., Genest, D.R., Wise, L., Bernstein, M.R., Goldstein, D.P. and Berkowitz, R.S. (2001) Placental site trophoblastic tumor: A 17-year experience at the New England Trophoblastic Disease Centre. Gynecologic Oncology, 82, 415-419. doi:10.1006/gyno.2001.6265
[10] International Federation of Obstetrics and Gynecology Oncology Committee (2002) FIGO staging for gestational trophoblastic neoplasia. International Journal of Gynecology & Obstetrics, 77, 285-287.
[11] Leiserowitz, G.S. and Webb, M.J. (1996) Treatment of placental site trophoblastic tumor with hysterotomy and uterine reconstruction. Obstetrics & Gynecology, 88, 696-699. doi:10.1016/0029-7844(96)00124-X
[12] Pfeffer, P.E., Sebire, N., Lindsay, I., McIndoe, A., Lim, A. and Seckl, M.J. (2007) Fertility-sparing partial hysterictomy for placental-site trophoblastic tumour. The Lancet Oncology, 8, 744-746. doi:10.1016/S1470-2045(07)70243-7
[13] Xue, W.C., Guan, X.Y., Ngan, H.Y., Shen, D.H., Khoo, U.S. and Cheung, A.N. (2002) Malignant placental site trophoblastic tumor, a cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization. Cancer, 94, 2288-2294. doi:10.1002/cncr.10424
[14] Usubütün, A. (2011) Gestational trophoblastic disease. Turkiye Klinikleri Journal of Medical Oncology Special Topics, 4, 48-53.

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