One-time injection of calcitonin induces glucose intolerance in children with the first degree obesity

Abstract

The effect of calcitonin on the blood glucose level in glucose-tolerance test of children with the first degree obesity was studied. Initial blood glucose level was normal and glucose-tolerance test per os didn’t expose glucose tolerance impairment in children under control. Calcitonin didn’t change initial glucose concentration but evoked impairment of glucose tolerance. The girls with the first degree obesity were more sensitive to hyperglycemic effect of calcitonin than the boys. Sex specificities must be taken into consideration in calcitonin treatment. Besides one ought mean that the increasing secretion of calcitonin occurs in stress-reactions. In these conditions endogenous calcitonin can make the same effect on the regulation of carbohydrate metabolism as exogenous injections of hormone.

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Moisa, S. and Nozdrachev, A. (2013) One-time injection of calcitonin induces glucose intolerance in children with the first degree obesity. Health, 5, 9-13. doi: 10.4236/health.2013.56A1002.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Rolland-Cachera, M.E., Peneau, S. and Bellisle, F. (2007) Metabolic syndrome definition in children: A focus on the different stages of growth. International Journal of Obesity, 31, 1760.
[2] Viner, R.M., Hindmarsh, P.S., Tayler, B. and Cole, T.I. (2008) Childhood body mass index (BMI), breastfeeding and risk of type I diabetes: Findings from a longitudinal national birth cohort. Diabetic Medicine, 25, 1056-1061. doi:10.1111/j.1464-5491.2008.02525.x
[3] Phelan, S., Wadden, T.A., Berkowitz, R.I., et al. (2007) Impact of weight loss on the metabolic syndrome. International Journal of Obesity, 31, 1442-1448. doi:10.1038/sj.ijo.0803606
[4] Ageeva, V.V., Krasil’nikova, E.I., Zubina, I.M. and Shlyakhto, E.V. (2002) Relation between insulin-resistance and lipid metabolism dysfunction in patients with obesity. Terapeutical Ackhiv, 74, 12-15.
[5] Finegood, D.T. (2003) Obesity, inflammation and type II diabetes. International Journal of Obesity, 27, 1-5. doi:10.1038/sj.ijo.0802490
[6] Nugent, A.P. (2004) The metabolic syndrome. Nutrition Bulletin, 29, 36-43. doi:10.1111/j.1467-3010.2004.00403.x
[7] Wilkin, T.Y. (2001) The accelerator hypothesis: Weight gain as the missing link between type I and type 2 diabetes. Diabetologia, 44, 914-922. doi:10.1007/s001250100548
[8] Lofgren, P., Hoffstedt, J., Naslund, E., et al. (2005) Protective and controlled studies of the actions of insulin and catecholamine in fat cells of obese women following weight reduction. Diabetologia, 48, 2334-2342. doi:10.1007/s00125-005-1961-6
[9] Muacevic-Katanec, D., Vetelko, Z., Busljeta, I. and Car, N. (2003) Recommendations on the approach to obese persons with diabetes mellitus. Diabetes Croatian, 32, 3- 15.
[10] Eriksson, J.G. (2006) Early growth, and coronary heart disease and type 2 diabetes: Experiences from the helsinki birth cohort studies. International Journal of Obesity, 30, 518-522.
[11] Dumie, M., Spehar, A. and Janjanin, N. (2004) Debelo dijete. Paediatr Croat, 1, 3-8.
[12] Dianov, O.A., Gnusaev, S.F., Yakovlev, B.N. and Gorshkova, M.I. (2008) Neurocirculatory instability and metabolic disturbances in children with obesity and their correction. Vestn. Pediatr. Farmakol. I Nutritsiol., 5, 34- 38.
[13] Zhu, J.-F., Liang, L., Wang, S.-L. and Zhou, C.-C. (2006) Distribution of complication in juveniles with moderate and heavy obesity. Journal of Applied Clinical Pediatrics, 21, 1320-1321.
[14] Zhang, X.N., Yu, S.G. and Li S.N. (2003) The level of insulin and c-peptide in the blood plasma of children with simple obesity. Journal of Applied Clinical Pediatrics, 18, 28-29.
[15] Liu, R.H., Mizuta, M., Kurose, T. and Matsukura, S. (2002) Early events involved in the development of insulin resistance in zuker fatty rats. International Journal of Obesity, 26, 318-326. doi:10.1038/sj.ijo.0801924
[16] Orlov, R.S. and Nozdrachev, A.D. (2006) Normal’naya fiziologiya (Common physiology), Moscow.
[17] Roitberg, G.E. (2007) Metabolicheskii sindrom (Metabolic syndrome). Moscow.
[18] Fox, K.R., Peters, D.M., Sharpe, P. and Bell, M. (2000) Assessment of abdominal fat development in young adolescents using magnetic resonance imaging. International Journal of Obesity and Related Metabolic Disorders, 24, 1653-1659. doi:10.1038/sj.ijo.0801464
[19] Krishnaveni, G.V., Veena, S.R., Hill, J.C., et al. (2010) Intrauterine exposure to maternal diabetes is associated with higher adiposity and insulin resistance and clustering of cardiovascular risk markers in Indian children. Diabetes Care, 33, 402-404. doi:10.2337/dc09-1393
[20] Dedov, I.I., Kuraeva, T.L. and Peterkova, V.A. (2008) Sakharnyi diabet u detei i podrostkov (Pancreatic diabetes in children and juveniles). GEOTAR-Media, Moscow.
[21] Pavlovskaya, E.V., Strokova, T.V., Surkov, A.G. and Kaganov, B.S. (2008) Obesity in children and juveniles— Present view on the problem. Vopr. Det. Dietol., 6, 27-36.
[22] Szurkowska, M., Szafraniec, K., Gilis-Januszewska, A., et al. (2006) Metabolic hazzars of obesity. Polish multicenter study on diabetes epidemiology: EA-EEF European Congress of Epidemiology “Epidemiology and Health Care Practice”. Utrecht, 29 June-1 July 2006, 141.
[23] Demidova, T.Y. and Kruglova, E.L. (2009) Obesity as a key and modifying reason causing the II type pancreatic diabetes. Russian Medicine, 7, 450.
[24] Cruz, M.L., Shaibi, G.Q., Weigensberg, M.J., et al. (2005) Pediatria obesity and insulin resistance: Chronic disease risk and implications for treatment and prevention beyond body weight modification. Annual Review of Nutrition, 25, 435-468. doi:10.1146/annurev.nutr.25.050304.092625
[25] Dubois, L. and Girand, M. (2006) Early determinations of overweight at 4.5 years in a population-based longitudinal study. International Journal of Obesity, 30, 610-617. doi:10.1038/sj.ijo.0803141
[26] Kahn, B.B. and Flier, J.S. (2000) Obesity and insulin resistance. International Journal of Obesity, 106, 473- 481.
[27] Freemark, M. (2010) Pediatric obesity in etiology, pathogenesis and treatment (Contemporary endocrinology). Humana Press, New York.
[28] Kovarenko, M.A. and Ruyatkina, L.A. (2006) Reflections on the debut of the metabolic syndrome in obese children with pink striae. Byul. Vost.-Sib. Nauch. Tsentra SO RAMN, 1, 22-26.
[29] Leont’eva, I.V. (2008) Metabolic syndrome as pediatric problem. Ros. Vestn. Perinatol. I Pediatr., 53, 4-16.
[30] Potemkin, V.V., Troitskaya, S.Y. and Tomilova, E.N. (2006) Pathophysiological mechanisms of insulin-resistance at obesity. Ros. Med. Zhurn., 2, 20-23.
[31] Druet, C., Dabbas, M., Baltakse, V., et al. (2006) Insulin resistance and the metabolic syndrome in obese french children. Endocrinology, 64, 672-678.
[32] Dedov, I.I., Mel’nichenko, G.A. and Fadeev, V.V. (1998) Endokrinologiya: Kratkii spravochnik (Endocrinology: Summary reference book). Moscow.
[33] Butakova (Moisa), S.S. and Nozdrachev, A.D. (2010) Calcitonin—Contra-insulin hormone. Advances of Gerontology, 23, 364-370.
[34] Gattereau, A., Bielmann, P., Durivage, J., et al. (1977) Hyperglycaemic effect of synthetic salmon calcitonin. Lancet, 310, 1076-1077. doi:10.1016/S0140-6736(77)91908-0
[35] Evans, I.M., Joplin, G.F. and Mac Intyre, J. (1977) Hyperglycaemic effect of synthetic salmon calcitonin. Lancet, 2, 1.76-1077.
[36] Freed, W.J., Perlow, M.J. and Wyatt, R.J. (1979) Calcitonin: Inhibitory effect on eating in rats. Science, 206, 850-852. doi:10.1126/science.493987
[37] Passariello, N., Guigliano, D., Sgambato, S., et al. (1981) Calcitonin, a diabetogenic hormone? The Journal of Clinical Endocrinology & Metabolism, 53, 318-323. doi:10.1210/jcem-53-2-318
[38] Drzhevetskaya, I.A., Mishina, N.F., Limanskii, N.N., et al. (1982) Secretion and functional reserve of calcitonin in man. Neuroendocrine Mechanisms of Adaptation. Stavropol, 4-12.
[39] Borodina, O.V., Odud, E.A., Timofeev, A.V., et al. (2003) Assessment of insulin resistance in children and adolescents with obesity. Problemy Endokrinologii/Problems of Endocrinology, 49, 8-11.
[40] Vasyukova, O.V. and Vitebskaya A.V. (2009) Insulin resistance under obesity in children: Argument of assessment. Problemy Endokrinologii/Problems of Endocrinology, 55, 8-13.
[41] Nozdrachev, A.D. (2002) The fundamentals of physiology. St.-Petersburg.
[42] Iaroshevskii, I.A., Darinskii, I.A. and Butakova (Moisa), S.S. (1989) Effect of calcitonin on insulin and glucagons secretion by the pancreas. Problemy Endokrinologii/Problems of Endocrinology, 35, 58-61.
[43] Young, A.A., Wang, M.W., Gedulin, B., et al. (1995) Diabetogenic effects of salmon calcitonin are attributable to amylin-like activity. Metabolism—Clinical and Experimental, 44, 1581-1589. doi:10.1016/0026-0495(95)90079-9

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