Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-Inflammatory Derived from 3-Aminobenzothieno[2,3-d]pyrimidines

DOI: 10.4236/ijoc.2013.32012   PDF   HTML     4,267 Downloads   7,347 Views   Citations


During the last few years, condensed thienopyrimidine derivatives have received considerable attention. The therapeutic importance of thienopyrimidines prompted us to synthesize some of spiro(benzothieno[2,3-d]pyrimidine-4-one) derivatives. Some of the novel benzothino-pyrimidine derivatives 3a, 9b, 10b, 11a, 11b, and 11c showed considerable potent anti-inflammatory and analgesic activity of superior G.I.T. safety profile in experimental rats in comparing to indomethacin and tramadol as reference drugs.

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H. Hafez, O. Al-Duaij and A. El-Gazzar, "Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-Inflammatory Derived from 3-Aminobenzothieno[2,3-d]pyrimidines," International Journal of Organic Chemistry, Vol. 3 No. 2, 2013, pp. 110-118. doi: 10.4236/ijoc.2013.32012.

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The authors declare no conflicts of interest.


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