Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-Inflammatory Derived from 3-Aminobenzothieno[2,3-d]pyrimidines

Hend Nagah Hafez, Omar Khalid Al-Duaij, Abdel-Rhman Barakat A. El-Gazzar

Chemistry Department, Faculty of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, KSA.
Photochemistry Department, National Research Centre, Cairo, Egypt.

DOI: 10.4236/ijoc.2013.32012                

Abstract

During the last few years, condensed thienopyrimidine derivatives have received considerable attention. The therapeutic importance of thienopyrimidines prompted us to synthesize some of spiro(benzothieno[2,3-d]pyrimidine-4-one) derivatives. Some of the novel benzothino-pyrimidine derivatives 3a, 9b, 10b, 11a, 11b, and 11c showed considerable potent anti-inflammatory and analgesic activity of superior G.I.T. safety profile in experimental rats in comparing to indomethacin and tramadol as reference drugs.

Keywords

Spirobenzothienopyrimidine; Triazolopyrimidine; Pyrazolopyrimidine; Analgesic; Anti-inflammatory; Ulcerogenic Effect

Conflicts of Interest

The authors declare no conflicts of interest.

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