No association between the GSTM1 and GSTT1 polymorphism and endometrial cancer risk: A meta-analysi

Marce-Amara Kpoghomou, Fatch W. Kalembo, Joella Eldie Soatiana

Department of Epidemiology and Biostatistics, School of Public Health, Tong Ji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Maternal and Child Health, School of Public Health, Tong Ji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Ophthalmology, Tong Ji Medical College, Huazhong University of Science and Technology, Wuhan, China.

DOI: 10.4236/ojog.2013.34072                

Abstract

Purpose: A number of case-control studies have been conducted to investigate the association of glutathione S-transferase (GST) genetic polymorphisms and endometrial carcinoma risk. However, these studies have yielded contradictory results. We therefore performed a meta-analysis to derive a more precise estimation of the association between polymorphisms on GSTM1, GSTT1 and endometrial carcinoma. Methods: Identification of relevant studies was carried out through a search in the following databases Medline, EMbase andChinaNational Knowledge International (CNKI) up to March. 2013. All case-control studies that investigated the association between GS-TM1 and GSTT1 gene polymorphisms and risk of endometrial cancer were included in the study. The pooled odds ratio (OR) was used for analyses of results and the corresponding 95% confidence intervals (CI) were estimated. Result: Six published case-control studies of association between the GSTM1 and GSTT1 polymorphism and endometrial cancer risk covering 3558 subjects were included in the metaanalysis, but the results indicated that the null genotypes of GSTM1 and GSTT1 polymorphisms were not associated with a significantly increased risk of endometrial cancer (for GSTM1: OR = 0.99; 95% CI, 0.86 - 1.4; for GSTT1: OR = 0.96; 95% CI, 0.80 - 1.14, respectively). Conclusion: This meta-analysis suggests that GSTM1 and GSTT1 polymorphism may not be associated with increased risk of endometrial cancer. To validate the association between polymorphism and endometrial cancer, further studies with larger numbers of participants worldwide are needed.

Keywords

GSTM1; GSTT1; Polymorphism; Endometrial Cancer; Meta-Analysis

Conflicts of Interest

The authors declare no conflicts of interest.

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