The activities of endothelial elastase and cathepsin G in rats at oxidative stress caused by heavy metals salts


CoCl2 introduction increased cathepsin G activity in the heart and liver as well as endothelial elastase (EEl) in kidney that indicated the development of destructive processes. CoCl2 introduction decreased EEl and cathepsin G activities in blood serum and cathepsin G in lungs. HgCl2 injection decreased EEl in blood serum, heart, liver, kidney and cathepsin G in blood serum. These decreasing of proteinases activities may be caused by cytotoxic effects of heavy metals and/or the inclusion of these proteases in the destructive processes and absence of their synthesis and/or release.

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Starodub, N. and Samokhina, L. (2013) The activities of endothelial elastase and cathepsin G in rats at oxidative stress caused by heavy metals salts. Advances in Biological Chemistry, 3, 208-214. doi: 10.4236/abc.2013.32026.

Conflicts of Interest

The authors declare no conflicts of interest.


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