[1]
|
G. Cragg, G. I. Kingston and D. Newman, “Anticancer Agents from Natural Products,” 2nd Edition, CRC Press, Boca Raton, 2011.
|
[2]
|
Y. Hitotsuyanagi, M. Fukuyo, K. Tsuda, M. Kobayashi, A. Ozeki, H. Itokawa and K. Takeya, “4-Aza-2,3-dehydro-4-deoxypodophyllotoxins: Simple Aza-Podophyllotoxin Analogues Possessing Potent Cytotoxicity,” Bioorganic & Medicinal Chemistry Letters, Vol. 10, No. 4, 2000, pp. 315-317. doi:10.1016/S0960-894X(99)00693-9
|
[3]
|
Y. L. Zhang, X. Guo, Y. C. Cheng and K. H. Lee, “Antitumor agents. 148. Synthesis and Biological Evaluation of Novel 4Beta-Amino Derivatives of Etoposide with Better Pharmacological Profiles,” Journal of Medicinal Chemistry, Vol. 37, No. 4, 1994, pp. 446-452.
doi:10.1021/jm00030a003
|
[4]
|
S. Goodwin, A. F. Smith and E. C. Horning, “Alkaloids of Ochrosia elliptica Labill,” Journal of the American Chemical Society, Vol. 81, No. 8, 1959, pp. 1903-1908.
doi:10.1021/ja01517a031
|
[5]
|
A. K. Mukherjee, S. Basu, N. Sarkar and A. C. Ghosh. “Advances in Cancer Therapy with Plant Based Natural Products,” Current Medicinal Chemistry, Vol. 16, No. 7, 2005, pp. 789-795.
|
[6]
|
P. L. Kuo, Y. L. Hsu, Y. C. Kuo, C. H. Chang and C. C. Lin, “The Anti-Proliferative Inhibition Ofellipticine in Human Breast MDA-MB-231 Cancer Cells Is through Cell Cycle Arrest and Apoptosis Induction,” Anticancer Drugs, Vol. 16 , No. 7, 2005 , pp. 789-795.
doi:10.1097/01.cad.0000171768.36317.93
|
[7]
|
S. K. Mantenan, S. D. Sharma and S. K. Katiyar, “Berberine Inhibits Growth, Induces G1 Arrest and Apoptosis in Human Epidermoid Carcinoma A431 Cells by Regulating Cdki-Cdk-Cyclin Cascade, Disruption of Mitochondrial Membrane Potential and Cleavage of Caspase 3 and PARP,” Oxford Journals, Vol. 27 , No. 10, 2006 , pp. 2018-2027. doi:10.1093/carcin/bgl043
|
[8]
|
M. Stiborova, M. Rupertova, H. H. Schmeiser and E. Frei, “Molecular Mechanisms of Antineoplastic Action of an Anticancer Drug Ellipticine,” Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, Vol. 150 , No. 1, 2006 , pp. 13-23.
|
[9]
|
O. Cox, H. Jackson, V. A. Vargas, A. Báez, J. I. Colón, B. C. González and M. de León, “Synthesis and Biological Activity of Benzothiazolo- and Benzoxazolo[3,2-a]quinolinium Salts,” Journal of Medicinal Chemistry, Vol. 25, No. 11, 1982, pp. 1378-1381. doi:10.1021/jm00353a020
|
[10]
|
C. A. Casiano and A. Báez, “Effects of the Antitumor Drugs 3-Nitrobenzothiazolo[3,2-alpha]quinolinium and Fagaronine on Nucleic Acid and Protein Synthesis,” Biochemical Pharmacology, Vol. 35, No. 4, 1986, pp. 679-685. doi:10.1016/0006-2952(86)90367-9
|
[11]
|
S. Mahata, A. C. Bharti, S. Shukla, A. Tyagi, S. A. Husain and B. C. Das, “Berberine Modulates AP-1 Activity to Suppress HPV Transcription and Downstream Signaling to Induce Growth Arrest and Apoptosis in Cervical Cancer Cells,” Molecular Cancer, Vol. 10, 2011, p. 39.
doi:10.1186/1476-4598-10-39
|
[12]
|
B. Zayas, J. Beyley, M. Terron, M. Cordero, W. Hernandez, A. E. Alegría and O. Cox, “Comparison of the Nucleic Acid Covalent Binding Capacity of Two Nitro-Substituted Benzazolo[3,2-a]quinolinium Salts upon Enzymatic Reduction,” Toxicology in Vitro, Vol. 21, No. 6, 2007, pp. 1155-1164.
|
[13]
|
I. G. Colón, F. A. González, M. Cordero, B. Zayas, C. Velez, O. Cox, A. Kumar and A. E. Alegría, “Role of the Nitro Functionality in the DNA Binding of 3-Nitro-10-methylbenzothiazolo[3,2-a]quinolinium Chloride,” Chemical Research in Toxicology, Vol. 21, No. 9, 2008, pp. 1706-1715. doi:10.1021/tx800076c
|
[14]
|
A. Baez, F. A. González, D. Vázquez and M. J. Waring, “Interaction between a 3-Nitrobenzothiazolo (3,2-a)quinolinium Antitumour Drug and Deoxyribonucleic Acid,” Biochemical Pharmacology, Vol. 32, No. 13, 1983, pp. 2089-2094. doi:10.1016/0006-2952(83)90431-8
|
[15]
|
A. E. Alegria, O. Cox, V. Santiago, M. Colon, Z. Reyes, L. Zayas, L. A. Rivera and J. A. Dumas, “Reductive Activation of Benzazolo[3,2-a]quinolinium Chlorides,” Free Radical Biology Medicine, Vol. 15, No. 1, 1993, pp. 49-56. doi:10.1016/0891-5849(93)90124-D
|
[16]
|
R. H. Shoemaker, “The NCI60 Human Tumour Cell Line Anticancer Drug Screen,” Nature Reviews Cancer, Vol. 6, No. 10, 2006, pp. 813-823.
|
[17]
|
S. L. Holbeck, J. M. Collins and J. H. Doroshow, “Analysis of Food and Drug Administration-Approved Anticancer Agents in the NCI60 Panel of Human Tumor Cell Lines,” Molecular Cancer Therapeutics, Vol. 9, No. 5, 2010, pp. 1451-1460.
|
[18]
|
A. I. Medvedev and V. V. Leshchenko, “Large-Scale Fragmentation of DNA and the Death of Tumor Cells by the Action of the Binary System Ascorbic Acid-Metallo-complexes of Cobalt in Vitro,” Tsitologiia, Vol. 54, No. 5, 2012, pp. 417-420.
|
[19]
|
H. Bakshi, S. Sam, R. Rozati, P. Sultan, T. Islam, B. Rathore, Z. Lone, M. Sharma, J. Triphati and R. C. Saxena, “DNA Fragmentation and Cell Cycle Arrest: a Hallmark of Apoptosis Induced by Crocin from Kashmiri Saffron in a Human Pancreatic Cancer Cell Line,” Asian Pacific Journal of Cancer Prevention, Vol. 11, No. 3, 2010, pp. 675-679.
|
[20]
|
L. Jacobs and R. DeMars, “Chemical Mutagenesis with Diploid Human Fibroblasts,” In: B. J. Kilbey, M. Legator, W. Nichols and C. Ramel, Eds., Handbook of Mutagenicity Test Procedures, Elsevier Science Publishers, Amsterdam, 1984, pp. 321-356.
|
[21]
|
M. Moreno, “Toxicología Ambiental. Evaluación de Riesgo para la Salud Humana,” McGraw-Hill/Interamericana de Espana, Espana, 2003.
|
[22]
|
N. Güngor, A. M. Knaapen, A. Munnia, M. Peluso, G. R. Haenen, R. K. Chiu, R. W. Godschalk and F. J. Van Schooten, “Genotoxic Effects of Neutrophils and Hypochlorous Acid,” Mutagenesis, Vol. 25, No. 2, 2010, pp. 149-154. doi:10.1093/mutage/gep053
|
[23]
|
J. C. Martinou and R. J. Youle, “Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics,” Developmental Cell, Vol. 21, No. 1, 2011, pp. 92-101.
|
[24]
|
S. L. Spencer and P. K. Sorger, “Measuring and Modeling Apoptosis in Single Cells,” Cell, Vol. 144, No. 6, 2011, pp. 926-939.
|
[25]
|
V. Kumar and S. V. Malhotra, “Study on the Potential Anti-Cancer Activity of Phosphonium and Ammonium-Based Ionic liquids,” Bioorganic & Medicinal Chemistry Letters, Vol. 19, No. 16, 2009, pp. 4643-4646.
|
[26]
|
S. V. Malhotra and V. Kumar, “A Profile of the in Vitro Anti-Tumor Activity of Imidazolium-Based Ionic Liquids,” Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 2, 2010, pp. 581-585.
|
[27]
|
M. Stiborová, J. Sejbal, L. Borek-Dohalská, D. Aimová, J. Poljaková, K. Forsterová, M. Rupertová, J. Wiesner, J. Hudecek, M. Wiessler and E. Frei, “The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and Ellipticine N2-Oxide,” Cancer Research, Vol. 64, No. 22, 2004, pp. 8374-8380.
|
[28]
|
J. Poljaková, T. Eckschlager, J. Hrebacková, J. Hraběta and M. Stiborová, “The Comparison of Cytotoxicity of the Anticancer Drugs Doxorubicin and Ellipticine to Human Neuroblastoma Cells,” Interdisciplinary Toxicology, Vol. 1, No. 2, 2010, pp. 186-189.
doi:10.2478/v10102-010-0036-9
|
[29]
|
S. Tateishi, “A Novel Rad18 Ubiqitin Ligase-Mediated Pathway for Repair of Camptothecin-Induced DNA Damage,” Cell Cycle, Vol. 10, No. 13, 2011, pp. 2057-2058.
doi:10.4161/cc.10.13.15840
|
[30]
|
A. Y. Chen, P. M. Chen and Y. J. Chen, “DNA Topoisomerase I Drugs and Radiotherapy for Lung Cancer,” Journal of Thoracic Disease, Vol. 4, No. 4, 2012, pp. 390-397.
|
[31]
|
G. Cragg, G. I. Kingston and D. Newman, “Anticancer Agents from Natural Products,” 2nd Edition, CRC Press, Boca Raton, 2011. doi:10.1201/b11185
|
[32]
|
N. Wu, X. W. Wu, K. Agama, Y. Pommier, J. Du, D. Li, L. Q. Gu, Z. S. Huang and L. K. An, “A Novel DNA Topoisomerase I Inhibitor with Different Mechanism from Camptothecin Induces G2/M Phase Cell Cycle Arrest to K562 Cells,” Biochemistry, Vol. 49, No. 47, 2010, pp. 10131-10136. doi:10.1021/bi1009419
|
[33]
|
A. Pozniak, L. Müller, M. Salgo, J. K. Jones, P. Larson and D. Tweats, “Elevated Ethyl Methanesulfonate (EMS) in Nelfinavir Mesylate (Viracept, Roche): Overview,” AIDS Research and Therapy, Vol. 6, 2009, p. 18.
doi:10.1186/1742-6405-6-18
|
[34]
|
M. Vayssier-Taussat, S. E. Kreps, C. Adrie, J. Dall’Ava, D. Christiani and B. S. Polla, “Mitochondrial Membrane Potential: A Novel Biomarker of Oxidative Environmental Stress,” Environmental Health Perspectives, Vol. 110, No. 3, 2002, pp. 301-305.
|
[35]
|
G. Kroemer, L. Galluzzi and C. Brenner, “Mitochondrial Membrane Permeabilization in Cell Death,” Physiological reviews, Vol. 87, No. 1, 2007, pp. 99-163.
|
[36]
|
M. Stiborová, J. Poljaková, E. Martínková, L. Borek-Dohalská, T. Eckschlager, R. Kizek, E. Frei, “Ellipticine Cytotoxicity to Cancer Cell Lines—A Comparative Study,” Interdisciplinary Toxicology, Vol. 4, No. 2, 2011, pp. 98-105. doi:10.2478/v10102-011-0017-7
|
[37]
|
J. Y. Kim, S. G. Lee, J. Y. Chung, Y. J. Kim, J. E. Park, H. Koh, M. S. Han, Y. C. Park, Y. H. Yoo and J. M. Kim, “Ellipticine Induces Apoptosis in Human Endometrial Cancer Cells: The Potential Involvement of Reactive Oxygen Species and Mitogen-Activated Proteinkinases,” Toxicology, Vol. 289, No. 2-3, 2011, pp. 91-102.
|
[38]
|
J. Nitiss, “Targeting DNA topoisomerase II in cancer chemotherapy,” Nature Reviews Cancer, Vol. 9, No. 5, 2009, pp. 338-350.
|
[39]
|
M. G. Ferlin, C. Marzano, V. Gandin, S. Dall’Acqua and L. Via Dalla, “DNA Binding Ellipticine Analogues: Synthesis, Biological Evaluation, and Structure-Activity Relationships,” ChemMedChem, Vol. 4, No. 3, 2009, pp. 363-377. doi:10.1002/cmdc.200800368
|
[40]
|
E. Martinkova, A. Maglott, D. Y. Leger, D. Bonnet, M. Stiborova, K. Takeda, S. Martin and M. Dontenwill, “Alpha5beta1 Integrin Antagonists Reduce Chemotherapy-Induced Premature Senescence and Facilitate Apoptosis in Human Glioblastoma Cells,” International Journal of Cancer, Vol. 127, No. 5, 2010, pp. 1240-1248.
doi:10.1002/ijc.25187
|
[41]
|
Y. C. Kuo, P. L. Kuo, Y. L. Hsu, C. Y. Cho and C. C. Lin, “Ellipticine Induces Apoptosis through P53-Dependent Pathway in Human Hepatocellular Carcinoma HepG2 Cells,” Life Sciences, Vol. 78, No. 22, 2006, pp. 2550-2557.
|
[42]
|
C. Chilampalli, R. Guillermo, R. S. Kaushik, A. Young, G. Chandrasekher, H. Fahmy and C. Dwivedi, “Honokiol, a Chemopreventive Agent against Skin Cancer, Induces Cellcycle Arrest and Apoptosis in Human Epidermoid A431 Cells,” Experimental Biology and Medicine (Maywood), Vol. 236, No. 11, 2011, pp. 1351-1359.
doi:10.1258/ebm.2011.011030
|
[43]
|
S. M. Meeran and S. K. Katiyar, “Grape Seed Proanthocyanidins Promote Apoptosis in Human Epidermoid Carcinoma A431 Cells through Alterations in Cdki-Cdk-Cyclin Cascade, and Caspase-3 Activation via Loss of Mitochondrial Membrane Potential,” Experimental Dermatology, Vol. 16, No. 5, 2007, pp. 405-415.
doi:10.1111/j.1600-0625.2007.00542.x
|
[44]
|
C. J. Norbury and B. Zhivotovsky, “DNA Damage-Induced Apoptosis,” Oncogene, Vol. 23, No. 16, 2004, pp. 2797-2808.
|
[45]
|
R. Tiwary, W. Yu, B. G. Sanders and K. Kline, “α-TEA Cooperates with Chemotherapeutic Agents to Induce Apoptosis of P53 Mutant, Triple-Negative Human Breast Cancer Cells via Activating P73,” Breast Cancer Research, Vol. 13, No. 1, 2011, p. R1. doi:10.1186/bcr2801
|
[46]
|
C. Lu, W. Wang and W. S. El-Deiry, “Non-Genotoxic Anti-Neoplastic Effects Ofellipticine Derivative NSC176327 in P53-Deficient Human Colon Carcinoma Cellsinvolve Stimulation of P73,” Cancer Biology & Therapy, Vol. 7, No. 12, 2008, pp. 2039-2046. doi:10.4161/cbt.7.12.7461
|
[47]
|
M. Hagg, M. Berndtsson, A. Mandic, R. Zhou, M. C. Shoshan and S. Linder, “Induction of Endoplasmic Reticulum Stress by Ellipticine Plant Alkaloids,” Molecular Cancer Therapeutics, Vol. 3, No. 4, 2004, pp. 489-497.
|
[48]
|
T. Nakano, H. Watanabe, M. Ozeki, M. Asai, H. Katoh, H. Satoh and H. Hayashi, “Endoplasmic Reticulum Ca2+ Depletion Induces Endothelial Cell Apoptosis Independently of Caspase-12,” Cardiovascular Research, Vol. 69, No. 4, 2006, pp. 908-915. doi:10.1016/j.cardiores.2005.11.023
|
[49]
|
W. X. Zong, C. Li, G. Hatzivassiliou, T. Lindsten, Q. C. Yu and J. Yuan, “Thompson CB. Bax and Bak Can Localize to the Endoplasmic Reticulum to Initiate Apoptosis,” The Journal of Cell Biology, Vol. 162, No. 1, 2003, pp. 59-69.
|
[50]
|
D. R. Green and J. C. Reed, “Mitochondria and Apoptosis,” Science, Vol. 281, No. 5381, 1998, pp. 1309-1312.
|