The Study of Influence of Silica and Polyethilene Glycols Organic-Inorganic Compounds on Free-Radical Processes in Vitro


In this study investigation of influence of hybrid nanosilica-polyethylene glycols materials (molecular weight 1500, 6000 and 15000), prepared by sol-gel synthesis, on lipid peroxidation and antioxidant activity of human serum in vitro was performed. Methods included chemiluminescence analysis and quantitative malonic dialdehyde estimation. It was revealed that nanosilica-PEG materials with different molecular weight had certain biological activity. Powders of SiO2-PEG 1500 and SiO2-PEG 6000 manifest prooxidant effects, whereas mesoporous (calcine) powders produced antioxidant effects in blood serum in vitro.

Share and Cite:

O. Sitnikova, S. Nazarov, I. Shikhanova, A. Agafonov, J. Dyuzhev and r. Popova, "The Study of Influence of Silica and Polyethilene Glycols Organic-Inorganic Compounds on Free-Radical Processes in Vitro," Pharmacology & Pharmacy, Vol. 1 No. 2, 2010, pp. 69-74. doi: 10.4236/pp.2010.12010.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] V. Z. Lankin, A. K. Tikhadze and Y. N. Belenkov, “Free-Radical Processes in Cardiovascular Diseases,” Kardiologiya, Vol. 40, No. 7, 2000, pp. 48-61. (in Russian).
[2] J. Fujii, Y. Iuchi and F. Okada, “Fundamental Roles of Reactive Oxygen Species and Protective Mechanisms in the Female Reproductive System,” Reproductive Biology and Endocrinology, No. 3, 2005, p. 43.
[3] V. A. Terekhina and Y. A. Petrovich, “Free-radical Oxidation and Antioxidant system,” Proper Economic Resource Management, 2005, p. 69 (in Russian).
[4] A. P. Golikov, P. P. Golikov and V. B. Davydov, “Influence of Mexidol on Oxidative Stress in Cerebral Form of Hypertensic Crisis,” Kardiologiya, Vol. 42, No. 3, 2002, pp. 25-29. (in Russian).
[5] L. A. Mansurova, O. V. Fedchishin, V. V. Trofimov, T. G. Zelenina and L. E. Smolyanko, “Physiological Role of Silicium,” Sibirskiy Meditsinskiy Zhurnal, No. 7, 2009, pp. 16-18. (in Russian).
[6] H.-M. Shen, Z. Zhang, Q.-F. Zhang and C.-N. Ong, “Reactive Oxygen Species and Caspase Activation Mediate Silica-Induced Apoptosis in Alveolar Macrophages,” American Journal of Physiology Lung Cellular and Molecular Physiology, Vol. 280, No. 1, 2001, pp. 10-17.
[7] E. G. Barrett, C. Johnston, G. Oberd?rster and J. N. Finkelstein, “Silica-Induced Chemokine Expression in Alveolar Type Ii Cells Is Mediated by Tnf-induced Oxidant Stress,” American Journal of Physiology Lung Cellular and Molecular Physiology, Vol. 276, No. 6, 1999, pp. 979-988.
[8] M. Ding, X. Shi, Y. J. Lu, C. Huang, S. Leonard, J. Roberts, et al., “Induction of Activator Protein-1 through Reactive Oxygen Species by Crystalline Silica in JB6 Cells,” Journal of Biological Chemistry, Vol. 276, No. 12, 2001, pp. 9108-9114.
[9] M. Ishihara, “Studies on Lipoperoxide of Normal Pregnant Women and Patient Toxemia of Pregnancy,” Clinica Chimica Acta, Vol. 84, No. 1-2, 1978, pp. 1-9.
[10] R. Stangl, W. Platzer and V. Wittwer, “IR Emission Spectroscopy of Silica Aerogel,” Journal of Non-Cry- stalline Solids, Vol. 186, 1995, pp. 256-263.
[11] M. A. S. Pedroso, M. L. Dias and C. Azuma, and C. G. Mothe, “Hydrocarbon Dispersion of Nanospherical Silica by Sol-Gel Process. 1. Tetraethoxysilane Homopolymerization,” Colloid and Polymer Science, Vol. 278, No. 12, 2000, pp. 1180-1186.
[12] R. Urlaub, U. Posset and R. Thull, “FT-IR Spectroscopic Investigations on Sol-gel-derived Coatings from Acid-Modified Titanium Alkoxides,” Journal of Non-Crystalline Solids, Vol. 256, 2000, pp. 276-284.
[13] R. L. Derosa and J. A. Trapasso, “Poly(Ethylene Glycol) Interactions with Alumina and Silica Powders Determined via DRIFT,” Journal of Materials Science, Vol. 37, No. 6, 2002, pp. 1079-1082.
[14] B. Lee, Y. Kim, H. Lee and J. Yi, “Synthesis of Functionalized Porous Silicas via Templating Method as Heavy Metal Ion Adsorbents: The Introduction of Surface Hydrophilicity onto the Surface of Adsorbents,” Microporous and Mesoporous Materials, Vol. 50, No. 1, 2001, pp. 77-90.
[15] H. S. Mansur, W. L. Vasconcelos, R. F. S. Lenza, R. L. Orefice, E. F. Reis and Z. P. Lobato, “Sol-Gel Silica Based Networks with Controlled Chemical Properties,” Journal of Non-Crystalline Solids, Vol. 273, No. 1-3, 2000, pp. 109-115.
[16] X. Li and T. A. King, “Spectroscopic Studies of Sol-Gel-Derived Organically Modified Silicates,” Journal of Non-Crystalline Solids, Vol. 204, No. 3, 1996, pp. 235-242.
[17] S.-H. Rhee, J.-Y. Choi and H.-M. Kim, “Preparation of a Bioactive and Degradable Poly(ε-caprolactone)/silica Hybrid through a Sol-gel Method,” Biomaterials, Vol. 23, No. 24, 2002, pp. 4915-4921.
[18] J. Gallardo, A. Duran, D. Di Martino and R. M. Almeida, “Structure of Inorganic and Hybrid SiO2 Sol-Gel Coatings Studied by Variable Incidence Infrared Spectroscopy,” Journal of Non-Crystalline Solids, Vol. 298, No. 2-3, 2002, pp. 219-225.
[19] V. A. Maroni and S. J. Epperson, “An in Situ Spectroscopic Investigation of the Pyrolysis of Ethylene Glycol Encapsulated in Silica Solidate,” Vibrational Spectroscopy, Vol. 27, No. 1, 2001. pp. 43-51.
[20] A. I. Zhuravlev and A. I. Zhuravleva, “Hiperweak Luminescence of Blood Serum and its Role in Complex Diagnostics,” Meditsina Press, Moscow, 1976. (in Russian).
[21] E. I. Kuzmina, A. S. Nelubin and M. K. Schennikova, “Application of Induced Chemiluminescence for Free- Radical Processes Estimation in Biological Substrates,” In: Biokhimiya i biofizika, Gorkiy, 1983, pp. 179-183. (in Russian).

Copyright © 2021 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.