Biodegradable Chitosan/Multiwalled Carbon Nanotube Composite for Bone Tissue Engineering

Imelda Olivas-Armendariz, Santos Adriana Martel-Estrada, Mónica E. Mendoza-Duarte, Florinda Jiménez-Vega, Perla García-Casillas, Carlos A. Martínez-Pérez

Advanced Materials Research Center, CIMAV, Chihuahua, México.
Institute of Biomedical Sciences, Autonommous University of Juarez City, Ciudad Juarez, México.
Institute of Engineering and Technology, Autonommous University of Juarez City, Ciudad Juarez, México.
Instituto of Design and Art, Autonommous University of Juarez City, Ciudad Juarez, México.

DOI: 10.4236/jbnb.2013.42025                

Abstract

In this work the influence of multiwalled carbon nanotubes (MWCNT) on mechanical properties was evaluated also the osteoinduction mechanism in Chitosan/MWCNT composite is reported. The morphology and the mechanical properties of the scaffolds were controlled by varying solvent ratios, quenching temperatures and carbon nanotubes concentration. In vitro cell culture of Sprague-Dawley rat’s osteoblasts was used to evaluate the phenotype expression of cells in the scaffolds. The presence of MWCNT in a chitosan matrix improving its mechanical properties and sustain osteoblast growth and differentiation that represent a potential application of the Chitosan/MWCNT as biomaterial for bone tissue engineering.

Keywords

Bone Tissue Regeneration; Chitosan; Multiwalled Carbon Nanotubes; Composite

Conflicts of Interest

The authors declare no conflicts of interest.

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