Effect of Calcium and Strontium on Mesoporous Titania Coatings for Implant Applications

Kathryn Grandfield, Shiuli Pujari, Marjam Ott, Håkan Engqvist, Wei Xia

Applied Materials Science, Department of Engineering Sciences, ?ngstr?m Laboratory, Uppsala University, Uppsala, Sweden.

DOI: 10.4236/jbnb.2013.42014                

Abstract

Increasing interest in the role of ions such as calcium and strontium in bone formation has called for the investigation of multifunctional ion-doped implant coatings. Mesoporous titania coatings incorporating calcium or strontium enabled a unique pore morphology and potential for drug delivery. Coatings were produced on titanium by an evaporation induced self-assembly method with the addition of calcium or strontium to the sol causing a shift in morphology from a hexagonally-packed to a worm-like porous network. Pore sizes ranged from 3.8 - 5 nm and coatings exhibited high surface areas between 181 - 215.5 m²/g, as measured by N₂ adsorption-desorption. Coatings were loaded with 1 mg/ml Cephalothin, and showed sustained release of the antibiotic over one week in vitro. Cell studies confirmed that the ion addition had no toxic effect on human-like osteoblastic SaOS-2 cells. The results of this study suggest the potential for mesoporous coatings with calcium or strontium incorporation for direct bone-interfacing and combined drug delivery implant applications.

Keywords

Mesoporous; Titania; Calcium; Strontium; Drug Delivery; Bone; EISA

Conflicts of Interest

The authors declare no conflicts of interest.

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