Angiosarcoma of the mandible: Metastasis from a primary tumor of the right atrium of the heart

Anwar Ramadhan, Helena Willén, Andreas Thor

Department of Plastic & Oral and Maxillofacial Surgery Institute of Surgical Sciences, Uppsala University, Uppsala, Sweden.

DOI: 10.4236/crcm.2013.21015                

Abstract

Angiosarcoma of the heart is a rare tumor with very poor prognosis especially in a patient with multiple metastases. We present a case of a 39-year-old woman with angiosarcoma of the heart metastasing to the right side of the mandible, a situation not often found previously in the literature.

Keywords

Angiosarcoma; Heart; Pathological Fracture; Metastasis; Mandible

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Skubitz, K.M. and D’Adamo, D.R. (2007) Sarcoma. Mayo Clinic Proceedings, 82, 1409-1432. doi:10.4065/82.11.1409
[2]	Young, R.J., Brown, N.J., Reed, M.W., Hughes, D. and Woll, P.J. (2010) Angiosarcoma. The Lancet Oncology, 11, 983-991. doi:10.1016/S1470-2045(10)70023-1
[3]	Lydiatt, W.M., Shaha, A.R. and Shah, J.P. (1994) Angiosarcoma of the head and neck. American Journal of Surgery, 168, 451-454. doi:10.1016/S0002-9610(05)80097-2
[4]	Fanburg-Smith, J.C., Furlong, M.A. and Childers, E.L. (2003) Oral and salivary gland angiosarcoma: A clinicopathologic study of 29 cases. Modern Pathology, 16, 263-271. doi:10.1097/01.MP.0000056986.08999.FD
[5]	Munoz, M., Monje, F., Alonso del Hoyo, J.R. and Martin-Granizo, R. (1998) Oral angiosarcoma misdiagnosed as a pyogenic granuloma. Journal of Oral and Maxillofacial Surgery, 56, 488-491. doi:10.1016/S0278-2391(98)90719-4
[6]	Penel, N., Mallet, Y., Robin, Y.M., Fournier, C., Grosjean, J., Ceugnart, L., et al. (2008) Prognostic factors for adult sarcomas of head and neck. International Journal of Oral and Maxillofacial Surgery, 37, 428-432. doi:10.1016/j.ijom.2008.01.019
[7]	Hirshberg, A., Shnaiderman-Shapiro, A., Kaplan, I. and Berger, R. (2008) Metastatic tumours to the oral cavity— Pathogenesis and analysis of 673 cases. Oral Oncology, 44, 743-752. doi:10.1016/j.oraloncology.2007.09.012
[8]	Kraus, D.H., Dubner, S., Harrison, L.B., Strong, E.W., Hajdu, S.I., Kher, U., et al. (1994) Prognostic factors for recurrence and survival in head and neck soft tissue sarcomas. Cancer, 74, 697-702. doi:10.1002/1097-0142(19940715)74:2<697::AID-CNCR2820740224>3.0.CO;2-A
[9]	Penel, N., Van Haverbeke, C., Lartigau, E., Vilain, M.O., Ton Van, J., Mallet, Y., et al. (2004) Head and neck soft tissue sarcomas of adult: Prognostic value of surgery in multimodal therapeutic approach. Oral Oncology, 40, 890897. doi:10.1016/j.oraloncology.2004.04.001
[10]	Sengun, D., Tuncer, I., Ertem, N. and Sengun, O. (1986) Metastatic hemangioendotheliosarcoma of the mandible: Report of case. Journal of Oral and Maxillofacial Surgery, 44, 806-810. doi:10.1016/0278-2391(86)90159-X
[11]	Favia, G., Lo Muzio, L., Serpico, R. and Maiorano, E. (2002) Angiosarcoma of the head and neck with intra-oral presentation: A clinico-pathological study of four cases. Oral Oncology, 38, 757-762. doi:10.1016/S1368-8375(02)00045-3
[12]	Murphy, M.C., Sweeney, M.S., Putnam Jr., J.B., Walker, W.E., Frazier, O.H., Ott, D.A., et al. (1990) Surgical treatment of cardiac tumors: A 25-year experience. The Annals of Thoracic Surgery, 49, 612-618. doi:10.1016/0003-4975(90)90310-3
[13]	Eisenberg, E., Natarajan, E., Yamase, H. and Hatzigiannis, G. (2007) Undifferentiated cardiac sarcoma metastatic to the maxilla: Report of a case. Journal of Oral and Maxillofacial Surgery, 65, 148-151. doi:10.1016/j.joms.2006.08.008
[14]	Carr, R.J. and Green, D.M. (1986) Oral presentation of disseminated angiosarcoma. British Journal of Oral and Maxillofacial Surgery, 24, 277-285. doi:10.1016/0266-4356(86)90094-X
[15]	Weber, R.S., Benjamin, R.S., Peters, L.J., Ro, J.Y., Achon, O. and Goepfert, H. (1986) Soft tissue sarcomas of the head and neck in adolescents and adults. American Journal of Surgery, 152, 386-392. doi:10.1016/0002-9610(86)90309-0
[16]	Coindre, J.M., Terrier, P., Guillou, L., Le Doussal, V., Collin, F., Ranchere, D., et al. (2001) Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: A study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group. Cancer, 91, 1914-1926. doi:10.1002/1097-0142(20010515)91:10<1914::AID-CNCR1214>3.0.CO;2-3
[17]	Wang, C., Rabah, R., Blackstein, M. and Riddell, R.H. (2004) Bone marrow metastasis of angiosarcoma. Pathology—Research and Practice, 200, 551-555. doi:10.1016/j.prp.2004.05.003
[18]	Khodayari, A. and Khojasteh, A. (2005) Mandibular pathologic fracture as a first sign of disseminated angiosarcoma: A case report and review of literatures. Oral Oncology, 41, 178-182. doi:10.1016/j.ooe.2005.05.001