Radiation associated coronary occlusion: Overlooked as trastuzumab-induced cardiomyopathy

Ugur Turk, Veysel Yavuz, Nurullah Cetin

Department of Cardiology, Celal Bayar University, Manisa, Turkey.
Department of Cardiology, Central Hospital, Izmir, Turkey.

DOI: 10.4236/ojim.2013.31001                

Abstract

Trastuzumab is an agent used for receptor-positive breast cancer. Up to a third of patients treated with trastuzumab might develop cardiomyopathy. Many patients with breast cancer have taken pre- or co-administration of mediastinal radiotherapy. Both of treatment modalities have toxic effects on myocardium. It may result with diagnostic confusion between radiation-induced CAD (riCAD) and trastuzumab cardiomyopathy in the case with dilated cardiomyopathy. TTE may offer clues of differential diagnosis.

Keywords

Cardiomyopathy; Trastuzumab; Radiation

Conflicts of Interest

The authors declare no conflicts of interest.

References

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