Metabolic control of respiration and glycolysis of tumoral cells

DOI: 10.4236/abc.2013.31011   PDF   HTML   XML   5,069 Downloads   7,579 Views   Citations


The contribution of the author’s groups on the control of energy metabolism of cancer cells has been concisely reviewed. It is proposed that Otto Warburg’s “respiratory defect” of tumoral cells resides in an alteration of the recurrent filamentation cycle of mitochondria. These give those organelles an affinity lower for ADP than the affinity of the tumor cell isoenzyme of pyruvate kinase. These two findings may explain the essentials of the intimate mechanism of the aerobic glycolysis of cancer cells.

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Gosalvez, M. (2013) Metabolic control of respiration and glycolysis of tumoral cells. Advances in Biological Chemistry, 3, 86-89. doi: 10.4236/abc.2013.31011.

Conflicts of Interest

The authors declare no conflicts of interest.


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