Inorganic Molecularly Imprinted Polymer by Sol-Gel Process for Recognition of Caffeine


A molecularly imprinted polymer (MIP) was formed using an inorganic polymer by a sol-gel process. The monomers which were used to synthesize the inorganic polymer were tetraethoxysilane (TEOS), triethoxymethylsilane (MTES), and triethoxyphenylsilane (PTES). Caffeine was chosen as a template for the molecular imprinting, and theophylline was chosen as the analogous counterpart compound. The discriminating ability of the synthesized MIP to these two-compounds was estimated in this study. The MIP showed the highest discriminating ability when the ratio of TEOS:MTES: PTES in the synthesis of the inorganic polymer was 1:1:3, the reaction temperature was 50?C, and the pH of the reaction system was ~6.5.

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M. Shin, Y. Shin and J. Shin, "Inorganic Molecularly Imprinted Polymer by Sol-Gel Process for Recognition of Caffeine," Open Journal of Organic Polymer Materials, Vol. 3 No. 1, 2013, pp. 1-5. doi: 10.4236/ojopm.2013.31001.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] R. Gupta and A. Kumar, “Molecular Imprinting in SolGel Matrix,” Biotechnology Advances, Vol. 26, No. 6, 2008, pp. 533-547.
[2] A. G. Mayes and K. Mosbach, “Molecularly Imprinted Polymers: Useful Materials for Analytical Chemistry,” Trends in Analytical Chemistry, Vol. 16, 1997, pp. 321332.
[3] S. W. Lee, D. H. Yang and T. Kunitake, “Regioselective Imprinting of Anthracenecarboxylic Acids onto TiO2 Gel Ultrathin Films: An Approach to Thin Film Sensor,” Sensors and Actuators B, Vol. 104, No. 1, 2005, pp. 35-42.
[4] D. H. Yang, N. Takahara, S. W. Lee and T. Kunitake, “Fabrication of Glucose-Sensitive TiO2 Ultrathin Films by Molecular Imprinting and Selective Detection of Monosaccharides,” Sensors and Actuators B, Vol. 130, No. 1, 2008, pp. 379-385.
[5] D. H. Yang, Y. R. Ham, M. H. Oh, Y. S. Yoon, J. S. Shin, Y. D. Kim and H. Kim, “Simple Method for the Fabrication of 1-Hydroxypyrene-Imprinted TiO2 Gel Nanofilms,” Current Applied Physics, Vol 9, No. 2, 2009, pp. e136e139. doi:10.1016/j.cap.2008.12.043
[6] K. Haupt and K. Mosbach, “Molecularly Imprinted Polymers and Their Use in Biomimetic Sensors,” Chemical Review, Vol. 100, No. 7, 2000, pp. 2495-2504.
[7] H. W. Sun, F. X. Qiao and G. Y.Liu, “Characteristic of Theophylline Imprinted Monolithic Column and Its Application for Determination of Xanthine Derivatives Caffeine and Theophylline in Green Tea,” Journal of Chromatography A, Vol. 1134, No. 1-2, 2006, pp. 194-200.
[8] J. Yin, G. Yang and Y. Chen, “Rapid and Efficient Chiral Separation of Nateglinide and Its l-Enantiomer on Monolithic Molecularly Imprinted Polymers,” Journal of Chromatography A, Vol. 1090, No. 1, 2005, pp. 68-75.
[9] P. D. Martin, G. R. Jones, F.Stringer and I. D.Wilson, “Comparison of Normal and Reversed-Phase Solid Phase Extraction Methods for Extraction of β-Blockers from Plasma Using Molecularly Imprinted Polymers,” Analyst, Vol. 128, No. 4, 2003, pp. 345-350.
[10] O. Bruggemann, A. Visnjevski, R. Burch and P. Patel, “Selective Extraction of Antioxidants with Molecularly Imprinted Polymers,” Analytica Chimica Acta, Vol. 504, No. 1, 2004, pp. 81-88.
[11] H. Yan and K. H. Row, “Molecularly Imprinted Monolithic Stationary Phases for Liquid Chromatographic Separation of Tryptophan and N-CBZ-Phenylalanine Enantiomers,” Biotechnology and Bioprocess Engineering, Vol. 11, 2006, pp. 357-363.
[12] D. Cunliffe, A. Kirby and C. Alexander, “Molecularly Imprinted Drug Delivery Systems,” Advanced Drug Delivery Reviews,” Vol. 57, No. 12, 2005, pp. 1836-1853.
[13] L. Tangbin, T. Xin and L. Songjun, “Selective Adsorption and Recognition by Molecularly Imprinted Polymer: A Study on Molecular Self-Assembly and Its Effect on Selectivity,” Polymer-Plastics Technology and Engineering, Vol. 46, No. 6, 2007, pp. 613-619.
[14] S. L. Kyung, S. K. Dae and S. K. Beom, “Biodegradable Molecularly Imprinted Polymers Based on Poly(ε-Caprolactone),” Biotechnology and Bioprocess Enginering, Vol. 12, No. 2, 2007, pp. 152-156.
[15] F. Keith, M. Edmond and R. Fiona, “Predicting the Performance of Molecularly Imprinted Polymers: Selective Extraction of Caffeine by Molecularly Imprinted Solid Phase Extraction,” Analytica Chimica Acta, Vol. 566, No. 1, 2006, pp. 60-68.
[16] Y. Hongyuan, J. Longmei and H. R. Kyung, “Special Selectivity of Molecularly Imprinted Monolithic Stationary Phase,” Journal of Liquid Chromatography and Related Technologies, Vol. 28, No. 20, 2005, pp. 31473155.
[17] S. C. Lee, H. M. Lin and H. Chen, “Studies on the Preparation and Properties of Inorganic Molecularly Imprinted Polymer (MIP) Based on Tetraethoxysilane and Silane Coupling Agents,” Journal of Applied Polymer Science, Vol. 114, No. 6, 2009, pp. 3994-3999.
[18] Y. J. Shin, M. H. Oh, Y. S. Yoon and J. S. Shin, “Hard Coatings on Polycarbonate Plate by Sol-Gel Reactions of Melamine Derivative, PHEMA, and Silicates,” Polymer Engineering and Science, Vol. 48, No. 7, 2008, pp. 12891295.

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