Nanostructures: Enhancing Potential Applications in Biomedicals


Nanotechnology is defined as the study and application of 1 - 100 nm sized structures. Nanomaterials have opened avenues for the industries and scientific endeavors. These recognized for unique size, dependant physical and chemical properties (optical, magnetic, catalytic, thermodynamic, electrochemical) [1]. Most significant properties of nanoparticles is their carbon strength. It is said to be so tough that recently with a nano-sized particles i.e. carbon nanotube—a bullet proof T-shirt/vests was manufactured. Nanotechnology were firstly proposed/initiated by Nobel Prize winner Richard Feynman in 1959 [2]. This science is credited to have applications ranging from electronics, biomedicals, food, fuel cells to biosensors and even fabrics. Though every field of science progressing but still faces some lacunae and that result in development of a new technology. The thriving biomedical techniques for disorders like cancers etc. is still in developmental stage where researchers and doctors are working hard for concrete therapeutic results from such nano-techniques. On Cancers, the harmful side effects of its treatment like chemotherapy can’t be left aside which is result of one of its drug delivery methods that don’t pinpoint their intended target cells accurately rather affects whole area. Researchers in universities like Harvard and MIT have been able to attach special RNA strands, measuring about 10nm in diameter, to nanoparticles and fill the nanoparticles with a chemotherapy drug. The RNA strands get attracted to cancer cells. When the nanoparticle encounters a cancer cell it adheres to it and releases the drug into the cancer cell. This directed method of drug delivery has great potential for treating cancer patients while producing less side harmful effects than those produced by conventional chemotherapy [3]. This paper provides valuable information to the researchers, knowledge experts and policy makers regarding the application of nanotechnology and its values in science and technology. Biomedical is one of the major issues which were catered by nanotechnology.

Share and Cite:

S. Singh, "Nanostructures: Enhancing Potential Applications in Biomedicals," Journal of Biomaterials and Nanobiotechnology, Vol. 4 No. 1, 2013, pp. 12-16. doi: 10.4236/jbnb.2013.41002.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] N. Sanvicens and M. P. Marco, “Multifunctional Nanoparticles—Properties and Prospects for Their Use in Human Medicine,” Trends in Biotechnology, Vol. 26, No. 8, 2008, pp. 425-433. doi:10.1016/j.tibtech.2008.04.005
[2] R. P. Feyn-man, “There’s Plenty of Room at the Bottom,” Annual Meeting of the American Physical Society, Pasadena, 29 December 1959.
[5] R. Lobenberg, “Smart Materials, Applications of Nanotechnologyin Drug Delivery and Drug Targeting,” Proceedings of the International Conference on MEMS, NANO, and Smart Systems (ICMENS’03), Bannf, 20-23 July 2003.
[6] U. A. Gunasekera, Q. A. Pankhurst and M. Douek, “Imaging Applications of Nanotechnology in Cancer,” Targeted Oncology, Vol. 4, No. 3, 2009, pp. 169-181. doi:10.1007/s11523-009-0118-9
[7] X.-H. Peng, et. al., “Targeted Magnetic Iron Oxide Nanoparticles for Tumor Im-aging and Therapy,” International Journal of Nanomedicine, Vol. 3, No. 3, 2008, pp. 311-321.
[8] B. Goldman, “Scientists Create Nanoparticles That Home in on Brain Tumor, Increasing Accuracy of Surgical Removal,” 2012.
[9] J. Gustafson and H. Ghandehari, “Silk-Elastinlike Protein Poly-mers for Matrix-Mediated Cancer Gene Therapy,” Advanced Drug Delivery Reviews, Vol. 62, No. 15, 2010, pp. 1509-1523. doi:10.1016/j.addr.2010.04.006
[10] J. Rajiv, et al., “Nanoburrs: A Novel Approach in the Treatment of Cardiovascular Disease,” International Research Journal of Pharmacy, Vol. 2, No. 5, 2011, pp. 91-92.
[11] J. R. McCarthy and R. Weissleder, “Multifunctional Magnetic Nanoparticles for Targeted Imaging and Therapy,” Advanced Drug Delivery Reviews, Vol. 60, No. 11, 2008, pp. 1241-1251. doi:10.1016/j.addr.2008.03.014
[12] J. Yang, C. H. Lee, H. J. Ko, J. S. Suh, H. G. Yoon, K. Lee, et al., “Multifunctional Magneto-Polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer,” Angewandte Chemie International Edition, Vol. 46, No. 46, 2007, pp. 8836-8839. doi:10.1002/anie.200703554
[13] Z. Medarova, W. Pham, C. Farrar, V. Petkova and A. Moore, “In Vivo Imaging of siRNA Delivery and Silencing in Tumors,” Nature Medicine, Vol. 13, No. 3, 2007, pp. 372-377. doi:10.1038/nm1486
[14] M. Ferrari, “Cancer Nanotechnology: Opportunities and Challenges,” Na-ture Reviews Cancer, Vol. 5, No. 3, 2005, pp. 161-171. doi:10.1038/nrc1566
[15] W. Bentley, “Nanofactories Enabling Nano-Based Drug Synthesis and Delivery.”
[16] S. Angelos et al., “pH Clock-Operated Mechanized Nanoparticles,” Journal of the American Chemical Society, Vol. 131, No. 36, 2009, pp. 12912-12914. doi:10.1021/ja9010157
[17] M. V. Yezhelyev, X. Gao, Y. Xing, A. Al-Hajj, S. Nie and R. M. O’Regan, “Emerging Use of Nanoparticles in Diagnosis and Treatment of Breast Cancer,” Lancet Oncology, Vol. 7, No. 8, 2006, pp. 657-667. doi:10.1016/S1470-2045(06)70793-8
[18] C. Loo, A. Lowery, N. Halas, J. West and R. Drezek, “Immunotargeted Nanoshells for Integrated Cancer Imaging and Therapy,” Nano Letters, Vol. 5, No. 4, 2005, pp. 709-711. doi:10.1021/nl050127s
[19] J. Lodhia, et al., “Development and Use of Nanoparticles (Part-1): Synthesis of Nanoparticles for MRI,” Biomedical Imaging and Intervention Journal, Vol. 6, No. 2, 2010, p. e12.
[20] Z. H. Cao, R. Tong, A. Mishra, W. C. Xu, G. C. L. Wong, J. J. Cheng and Y. Lu, “Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes,” Angewandte Chemie International Edition, Vol. 48, No. 35, 2009, pp. 6494-6498.
[21] L. J. Zhang and T. J. Webster, “Nanotechnology and Nanomaterials: Promises for Improved Tissue Regeneration,” Nano Today, Vol. 4, No. 1, 2009, pp.66-68. doi:10.1016/j.nantod.2008.10.014
[22] A. Khushu, 2011.
[23] K. H. Lee, et al., “Quantitative Characterization of the Lipid Encapsulation of Quantum Dots for Biomedical Ap-plications,” Nanomedicine: Nanotechnology, Biology and Med-icine, Vol. 8, No. 7, 2012, pp. 1190-1199.
[24] K.-A. D. Walker, C. Morgan, S. H. Doak and P. R. Dunstan, “Quantum Dots for Multiplexed Detection and Characterisation of Prostate Cancer Cells Using a Scanning Near-Field Optical Micro-scope,” PLoS ONE, Vol. 7, No. 2, 2012, e31592. doi:10.1371/journal.pone.0031592
[25] C. Fournier-Wirth and J. Coste, “Nanotechnologies for Pathogen Detection: Future Alternatives?” Biologicals, Vol. 38, No. 1, 2010, pp. 9-13. doi:10.1016/j.biologicals.2009.10.010
[26] P. DeShong, “Cell Surface Receptors Enabling Targeted Drug Delivery and Pa-thogen Detection.”
[27] C. Kaittanis, H. Bouk-hriss, S. Santra, S. A. Naser and J. M. Perez, “Rapid and Sensi-tive Detection of an Intracellular Pathogen in Human Peripheral Leukocytes with Hybridizing Magnetic Relaxation Nanosensors,” PLoS ONE, Vol. 7, No. 4, 2012, e35326 doi:10.1371/journal.pone.0035326

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.