Efficacy and Safety of Nasal Administration of “Na-no-L-DOPA” Based on PLGA Nanoparticles

DOI: 10.4236/eng.2012.410B007   PDF   HTML     3,119 Downloads   4,362 Views   Citations

Abstract

Inclusion of L-DOPA, the standard Parkinson’s disease medication, into polymeric particles (PLGA) results in optimization the drug metabolism and increasing its bioavailability, significantly increases of physical endurance, better coordination and lower anxiety in Wistar rats, when chronically administered nasally.

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I. Kondrasheva, T. Antipova, G. Barsegyan, P. Gambaryan, A. Guseva and A. Kamensky, "Efficacy and Safety of Nasal Administration of “Na-no-L-DOPA” Based on PLGA Nanoparticles," Engineering, Vol. 4 No. 10B, 2012, pp. 27-29. doi: 10.4236/eng.2012.410B007.

Conflicts of Interest

The authors declare no conflicts of interest.

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