Identification of the interactive region by the homology of the sequence spectrum

DOI: 10.4236/jbise.2010.39117   PDF   HTML     4,350 Downloads   8,127 Views   Citations


The base sequence in genome was governed by some fundamental principles such as reverse-complement symmetry, multiple fractality and so on, and the analytical method of the genome structure, the “Sequence Spectrum Method (SSM)”, based on the structural features of genomic DNA faithfully visualized these principles. This paper reported that the sequence spectrum in SSM closely reflected the biological phenomena of protein and DNA, and SSM could identify the interactive region of protein-protein and DNA-protein uniformly. In order to investigate the effectiveness of SSM we analyzed the several protein-protein and DNA-protein interaction published primarily in the genome of Saccharomyces cerevisiae. The method proposed here was based on the homology of sequence spectrum, and it advantageously and surprisingly used only base sequence of genome and did not require any other information, even information about the amino-acid sequence of protein. Eventually it was concluded that the fundamental principles in genome governed not only the static base sequence but also the dynamic function of protein and DNA.

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Nakahara, M. and Takeda, M. (2010) Identification of the interactive region by the homology of the sequence spectrum. Journal of Biomedical Science and Engineering, 3, 868-883. doi: 10.4236/jbise.2010.39117.

Conflicts of Interest

The authors declare no conflicts of interest.


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