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Epigenetics mechanisms and degenerative diseases

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DOI: 10.4236/ojgen.2012.24023    3,751 Downloads   6,522 Views   Citations

ABSTRACT

Epigenetic regulations are heritable changes in gene expression that occur in the absence of alterations in DNA sequences. Various epigenetic mechanisms include histone modifications and DNA methylations. In this review, we examine methods to study DNA methylations and their contribution to degenerative diseases by mediating the complex gene-by-environment interactions. Such epigenetic modifications despite being heritable and stably maintained are also potentially reversible and there is scope for the development of epigenetic therapies for this disease.


Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Joshi, K. , Bhat, S. , Deshpande, P. , Sule, M. and Satyamoorthy, K. (2012) Epigenetics mechanisms and degenerative diseases. Open Journal of Genetics, 2, 173-183. doi: 10.4236/ojgen.2012.24023.

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