Ultrasonically Assisted Synthesis of Aromatic Sulfonic Acids under Vilsmeier Haack Conditions in Acetonitrile Medium

Kamatala Chinna Rajanna, Purugula Venkanna, Mukka Satish Kumar, Soma Ram Gopal

Department of Chemistry, Osmania University, Hyderabad, India.

DOI: 10.4236/ijoc.2012.24046                

Abstract

Sulfonation of aromatic compounds (Phenols, Anilines) is triggered by Vilsmeier Haack (VH) reagent (DMF/POCl₃) or (DMF/SOCl₂) in the presence of NaHSO₃ under Sonication and conventional stirred conditions at room temperature. The reactions afforded corresponding Sulfonic acid derivatives in very good yields. The results obtained under Sonication were enhanced when compared with the yields of the conventional method.

Keywords

Vilsmeier Haack (VH) Reagent; Sulfonation; NaHSO₃; Sonication; Aromatic Compounds

Conflicts of Interest

The authors declare no conflicts of interest.

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