Effects of methanolic extract of Pausinystalia yohimbe bark on blood glucose level in normal fasting rats


Background: Pausinystalia yohimbe (L.) is a member of the family Rubiaceae. It is a valuable medicinal tree, distributed in evergreen closed-canopy forests in West Africa. It is traditionally used for treatment of erectile dysfunction and diabetes. Objective: This was an attempt to evaluate the effects of methanolic extract of P. yohimbe bark on blood glucose level in normal fasting rats. Methods: Different doses of methanolic extract of P. yohimbe bark (5, 10, 20, 40 and 80 mg/kg/mL) were orally administered to normal fasting rats to assess their effects on blood glucose levels. Results: The methanolic extract of P. yohimbe bark in different concentrations (5, 10, 20, 40 and 80 mg/kg/mL) when administered to normal fasting rats, only a considerable reduction (26.57 mg/dL) was produced by the dose of 20 mg/kg/mL. Conclusion and Recommendation: Although P. yohimbe has long been reported to regulate blood glucose levels; such effect is unclear and remains requiring further studies.

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Hassan, H. , Mohamed, T. , Ahmed, E. , Mohamed, A. and Sirag, N. (2012) Effects of methanolic extract of Pausinystalia yohimbe bark on blood glucose level in normal fasting rats. Health, 4, 1225-1228. doi: 10.4236/health.2012.412180.

Conflicts of Interest

The authors declare no conflicts of interest.


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