Comparison of a Pain Pump versus Injectable Medication for Analgesia in Knee Arthroscopy

Abstract

As arthroscopic knee procedures have evolved, so has the management of post-operative pain. Traditional pain management included intravenous narcotics, which often resulted in nausea and increased sedation. In an effort to reduce post-operative pain and minimize complications, the concept of multimodal analgesia evolved, including subcutaneous infiltration of local anesthetic, ketorolac and/or narcotic. We studied the effect upon post-operative pain of combining ropivacaine, ketorolac and morphine injected as a one-time dose compared to the same mixture plus an intraarticular pump administering ropivacaine for 24 hours. Our findings showed that a single subcutaneous and intraarticular injection of ketorolac, morphine and ropivacaine was as effective as this solution plus a 24-hour intraarticular ropivacaine pain pump for post-operative pain relief after outpatient arthroscopic knee surgery. No clinical or radiographic signs of chondrolysis were seen in the knee with the use of intraarticular ropivacaine at an average of 18 months post-operatively.

Share and Cite:

A. Pearsall, S. Madanagopal and K. Agrawal, "Comparison of a Pain Pump versus Injectable Medication for Analgesia in Knee Arthroscopy," Open Journal of Orthopedics, Vol. 2 No. 3, 2012, pp. 73-79. doi: 10.4236/ojo.2012.23015.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] N. N. Basu, B. Kald, and D. Heath, "Morphine Delays Discharge Following Ambulatory Surgery: A Prospective Institutional Study," Journal of Perioperative Practice, Vol. 19, No. 8, 2009, pp. 254-256.
[2] K. A. Faccenda, and B. T. Finucane, "Complications of Regional Anaesthesia Incidence and Prevention," Drug Safety, Vol. 24, No. 6, 2001, pp. 413-442. doi:10.2165/00002018-200124060-00002
[3] P. Essving, K. Axelsson, J. Kjellberg, O. Wallgren, A. Gupta, and A. Lundin, "Reduced Morphine Consumption and Pain Intensity with Local Infiltration Analgesia (LIA) Following Total Knee Arthroplasty," Acta Orthopaedica, Vol. 81, No. 3, 2010, pp. 354-360. doi:10.3109/17453674.2010.487241
[4] P. Essving, K. Axelsson, J. Kjellberg, O. Wallgren, A. Gupta, and A. Lundin, "Reduced Hospital Stay, Morphine Consumption, and Pain Intensity with Local Infiltration Analgesia After Unicompart-mental Knee Arthroplasty," Acta Orthopaedica, Vol. 80, No. 2, 2009, pp. 213-219. doi:10.3109/17453670902930008
[5] P. Gómez-Cardero, and E.C. Rodríguez-Merchán, "Postoperative Analgesia in TKA: Ropivacaine Continuous Intraarticular Infusion," Clinical Orthopaedics and Related Research, Vol. 468, No. 5, 2010, pp. 1242-1247. doi:10.1007/s11999-009-1202-2
[6] F. A. Barber, and M. A. Herbert, "The Effectiveness of an Anesthetic Continuous-Infusion Device on Postoperative Pain Control," Arthroscopy, Vol. 18, No. 1, 2002, pp. 76-81. doi:10.1053/jars.2002.25976
[7] H. Kehlet, and J. B. Dahl, "The Value of "Multimodal" or "Balanced Analgesia" in Post-operative Pain Treatment," Anesthesia & Analgesia, Vol. 77, No. 5, 1993, pp. 1048-1056. doi:10.1213/00000539-199311000-00030
[8] J. W. Jaureguito, J. F. Wilcox, S. J. Cohn, R. A. Thisted, and B. Reider, "A Comparison of Intraarticular Morphine and Bupivacaine for Pain Control After Outpatient Knee Arthroscopy. A Prospective, Randomized, Double-Blinded Study," The American Journal of Sports Medicine, Vol. 23, No. 3, 1995, pp. 350-353. doi:10.1177/036354659502300318
[9] A. Gupta, K. Axelsson, R. Allvin, J. Liszka-Hackzell, N. Rawal, B. Althoff, and B. G. Augustini, "Postoperative Pain Following Knee Arthroscopy: The Effects of Intra-Articular Ketorolac and/or Morphine," Regional Anesthesia and Pain Medicine, Vol. 24, No. 3, 1999, pp. 225-230. doi:10.1016/S1098-7339(99)90132-3
[10] J. Calmet, C. Esteve, S. Boada, and J. Giné, "Analgesic Effect of Intra-Articular Ketorolac in Knee Arthroscopy: Comparison of Morphine and Bupivacaine," Knee Surgery, Sports Traumatology, Arthroscopy, Vol. 12, No. 6, 2004, pp. 552-555.doi:10.1007/s00167-003-0483-3
[11] H. S. Feldman, "Toxicity of Local Anaesthetic Agents," in: S. Rice, and K. Fish, (Eds.), Anesthetic Toxicity, Raven Press, New York, 1994, pp. 107-133.
[12] D. D. Denson, J. A. Myers, C. T. Hartrick, C. P. Pither, D. E. Coyle, and P. P. Raj, "The Relationship Between Free Bupivacaine Concentration and Central Nervous System Toxicity," Anesthesiology, Vol. 61, 1984, pp. A211. doi:10.1097/00000542-198409001-00211
[13] H. F. Chew, N. A. Evans, and W. D. Stanish, "Patient-Controlled Bupivacaine Infusion into the Infrapatellar Fat Pad after Anterior Cruciate Ligament Reconstruction," Arthroscopy, Vol. 19, No. 5, 2003, pp. 500-505. doi:10.1053/jars.2003.50110
[14] H. R. Hoenecke, P. A. Pulido, B. A. Morris, and J. Fronek, "The efficacy of Continuous Bupivacaine Infiltration Following Anterior Cruciate ligament Reconstruction," Arthroscopy, Vol. 18, No. 8, 2002, pp. 854-858. doi:10.1053/jars.2002.36139
[15] M. Bianconi, L. Ferraro, G. C. Traina, G. Zanoli, T. Antonelli, A. Guberti, R. Ricci, and L. Massari, "Pharmacokinetics and Efficacy of Ropivacaine Continuous Wound Instillation after Joint Replacement Surgery," British Journal of Anaesthesia, Vol. 91, No. 6, 2003, pp. 830-835.doi:10.1093/bja/aeg277
[16] F. T. DeWeese, Z. Akbari, and E. Carline, "Pain Control after Knee Arthroplasty: Intraarticular versus Epidural Anesthesia," Clinical Orthopaedics and Related Research, Vol. 392, 2001, pp. 226-231. doi:10.1097/00003086-200111000-00028
[17] J. Nechleba, V. Rogers, G. Cortina, and T. Cooney, "Continuous Intra-Articular Infusion of Bupivacaine for Postoperative Pain Following Total Knee Arthroplasty," The Journal of Knee Surgery, Vol. 18, No. 3, 2005, pp. 197-202.
[18] J. W. Alford, and P. D. Fadale, "Evaluation of Postoperative Bupivacaine Infusion for Pain Management after Anterior Cruciate Ligament Reconstruction," Arthroscopy, Vol. 19, No. 8, 2003, pp. 855-861. doi:10.1016/S0749-8063(03)00734-5
[19] D. Townshend, K. Emmerson, S. Jones, P. Partington, and S. Muller, "Intra-Articular Injection versus Portal Infiltration Of 0.5% Bupivacaine Following Arthroscopy Of The Knee: A Prospective, Randomised Double-Blinded Trial," The Journal of Bone and Joint Surgery. British volume, Vol. 91, No. 5, 2009, pp. 601-603. doi:10.1302/0301-620X.91B5.21932
[20] R. D. Altman, and R. Moskowitz, "Intraarticular Sodium Hyaluronate (Hyalgan) In the Treatment of Patients with Osteoarthritis of the Knee: A Randomized Clinical Trial. Hyalgan Study Group," The Journal of Rheumatology, Vol. 25, No. 11, 1998, pp. 2203-2212.
[21] E. C. Huskisson, and S. Donnelly, "Hyaluronic Acid in the Treatment of Osteoarthritis of the Knee," Rheumatology (Oxford), Vol. 38, No. 7, 1999, pp. 602-607. doi:10.1093/rheumatology/38.7.602
[22] C. R. Chu, C. H. Coyle, C. T. Chu, M. Szczodry, V. Seshadri, J. C. Karpie, K. M. Cieslak, and E. K. Pringle, "In Vivo Effects of Single Intra-Articular Injection of 0.5% Bupivacaine on Articular Cartilage," The Journal of Bone and Joint Surgery. American volume, Vol. 92, No. 3, 2010, pp. 599-608. doi:10.2106/JBJS.I.00425
[23] J. L. Dragoo, T. Korotkova, R. Kanwar, and B. Wood, "The Effect of Local Anesthetics Administered via Pain Pump on Chondrocyte Viability," The American Journal of Sports Medicine, Vol. 36, No. 8, 2008, pp. 1484-1488. doi:10.1177/0363546508318190
[24] C. R. Chu, N. J. Izzo, C. H. Coyle, N. E. Papas, and A. Logar, "The in Vitro Effects of Bupivacaine on Articular Chondrocytes," The Journal of Bone and Joint Surgery. British volume, Vol. 90, No. 6, 2008, pp. 814-820. doi:10.1302/0301-620X.90B6.20079
[25] V. Grishko, M. Xu, G. Wilson, and A. W. Pearsall, "Apoptosis and Mitochondrial Dysfunction in Human Chondrocytes Following Exposure to Lidocaine, Bupivacaine, and Ropivacaine," The Journal of Bone and Joint Surgery. American volume, Vol. 92, No. 3, 2010, pp. 609-618.doi:10.2106/JBJS.H.01847
[26] J. M. Malinovsky, and H. Ludot, "Severe Chondrolysis after Shoulder Arthroscopy: A Case Series," Annales Francaises d'Anesthésie et de Réanimation, Vol. 28, No. 11, 2009, pp. 999-1000.
[27] P. P. Mariani, R. Garofalo, and F. Margheritini, "Chondrolysis after Partial Lateral Meniscectomy in Athletes," Knee Surgery, Sports Traumatology, Arthroscopy, Vol. 16, No. 6, 2008, pp. 574-580. doi:10.1007/s00167-008-0508-z
[28] J. H. Rapley, R. C. Beavis, and F. A. Barber, "Glenohumeral Chondrolysis after Shoulder Arthroscopy Associated with Continuous Bupivacaine Infusion," Arthroscopy, Vol. 25, No. 12, 2009, pp. 1367-1373. doi:10.1016/j.arthro.2009.08.024
[29] P. T. Scheffel, J. Clinton, J. R. Lynch, W. J. Warme, A. L. Bertelsen, and F. A. Matsen, "Glenohumeral Chondrolysis: A Systematic Review of 100 Cases From The English Language Literature," Journal of Shoulder and Elbow Surgery, Vol. 19, No. 6, 2010, pp. 944-949. doi:10.1016/j.jse.2010.01.023
[30] E. W. Fester, and F. R. Noyes, "Postoperative Chondrolysis of the Knee: 3 Case Reports and A Review of the Literature," The American Journal of Sports Medicine, Vol. 37, No. 9, 2009, pp. 1848-1854. doi:10.1177/0363546509334999
[31] M. T. Provencher, M. Navaie, D. J. Solomon, J. C. Smith, A. A. Romeo, and B. J. Cole, "Joint Chondrolysis," The Journal of Bone and Joint Surgery. American volume, Vol. 93, No. 21, 2011, pp. 2033-2044. doi:10.2106/JBJS.J.01931

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.