Realization Feature of Mesenchymal Dermal Cells Tissue Engineering Construction Response in Granulating Wound Transplantation in Relation with Time-Frame

DOI: 10.4236/jcdsa.2012.23024   PDF   HTML     5,697 Downloads   7,636 Views   Citations


Derma is progenitor cells sours, that are able to differentiate further in several mesodermal lineage and neural and endodermal lineage. Culture conditions, skin taking site and culture medium composition considerably contribute to it. Spheroid cultured mesenchymal dermal cells contribution to skin regeneration in granulating wound in rat model was estimated.

Share and Cite:

E. Petersen, "Realization Feature of Mesenchymal Dermal Cells Tissue Engineering Construction Response in Granulating Wound Transplantation in Relation with Time-Frame," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 2 No. 3, 2012, pp. 126-129. doi: 10.4236/jcdsa.2012.23024.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] J. Toma, M. Akhavan, K. Fernandes, et al., “Isolation of Multipotent Adult Stem Cells from the Dermis of Mammalian Skin,” Nature Cell Biology, Vol. 3, No. 9, 2001, pp. 778-784.
[2] J. Toma, I. McKenzie, D. Bagli, et al., “Isolation and Characterization of Multipotent Skin-Derived Precursors from Human Skin,” Stem Cells, Vol. 23, No. 6, 2005, pp. 727-737. doi:10.1634/stemcells.2004-0134
[3] J.-F. Lavoie, J. Biernaskie, Y. Chen, et al., “Skin-Derived Precursors Differentiate into Skeletogenic Cell Types and Contribute to Bone Repair,” Stem Cells and Development, Vol. 18, No. 6, 2009, pp. 893-905. doi:10.1089/scd.2008.0260
[4] M. Sieber-Blum, M. Grim, Y. Hu and V. Szeder, “Pluripotent Neural Crest Stem Cells in the Adult Hair Follicle,” Developmental Dynamics, Vol. 231, No. 2, 2004, pp. 258-269. doi:10.1002/dvdy.20129
[5] F. Chen, W. Zhang, D. Bi, et al., “Clonal Analysis of Nestin- Vimentin+ Multipotent Fibroblasts Isolated from Human Dermis,” Journal of Cell Science, Vol. 120, 2007, pp. 2875-2883. doi:10.1242/jcs.03478
[6] D. Bi, F. Chen, W. Zhang, D. Bi, et al., “Differentiation of Human Multipotent Dermal Fibroblast into Islet-Like Cell Cluster,” BMC Cell Biology, Vol. 11, No. 46, 2010, pp. 1-7.
[7] I. Saburina and V. Repin, “3D-Culturing from Single Cells to the Regeneration of Tissue (the Question about the Phenomenon of Epithelial-Mesenchymal Plasticity),” Cell Transplantation and Tissue Engineering, Vol. 5, No. 2, 2010, pp. 75-86.
[8] A. Gorkun, I. Saburina, N. Kosheleva, A. Pulin and V. Repin, “Induction of Vasculogenesis in the Spheroid of the Stromal Cells of Umbilical Cord,” Tula Journal New Medical Technologies, 2012, in press.

comments powered by Disqus

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.