Isolated gonadotropin deficiency with primary empty sella: Causal or casual association?


Empty sella is a radiological-anatomical entity characterised by a sella turcica filled partially or completely with cerebrospinal fluid, leading to varying degrees of pituitary flattening. Literature reports a 5% - 20% incidence of empty sella in unselected autopsies leading many to argue that its an extreme normal variant. Endocrine dysfunction varies from 8% - 25% with primary empty sella with growth hormone deficiency being most common. However isolated gonadotropin deficiency with normal sized primary empty sella are rare if any. We are reporting a case of isolated gonadotropin deficiency with primary empty sella unable to confirm or refute the association as causal or casual.

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Shekhar, S. , Sharma, C. , Surya, M. and Aggarwal, N. (2012) Isolated gonadotropin deficiency with primary empty sella: Causal or casual association?. Open Journal of Obstetrics and Gynecology, 2, 276-278. doi: 10.4236/ojog.2012.23057.

Conflicts of Interest

The authors declare no conflicts of interest.


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