Extirpolation of the Mythology that Porotic Hyperostosis is Caused by Iron Deficiency Secondary to Dietary Shift to Maize

Abstract

Diagnosing a shift to a maize-dominant diet, on the basis of recognition of high population frequencies of porotic hyperostosis, has unfortunately entered the “collective consciousness” of anthropology—because of the mythology that iron deficiency is a common cause of that phenomenon. Skull changes in patients with all forms (both primary and secondary) of iron deficiency are actually extremely rare (0.68%!). That frequency certainly does not support iron deficiency as the explanation for the high frequency of porotic hyperostosis noted (approximating 50%) in some populations. Isotopic analysis further reveals that C4 grasses (e.g., maize) actually did not become a significant part of North American human diets until the past 1000 years, long after notation of high frequency porotic hyperostosis. This further falsifies claims of earlier maize diets (predicated on frequency of porotic hyperostosis) and negates the perception that maize-induced iron deficiency is the cause of porotic hyperostosis. The latter speculation is not only con- trary to medical evidence, but that misdirection gave false impressions of ancient populations/civilizations and compromised use of a valuable observation. That mythology must be extirpated from the “collective consciousness”. Perhaps now attention can be appropriately directed to exploration of genetic hemolytic anemia, hemoglobinopathies and parasitic infestations which are known causes of porotic hyperostosis.

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Rothschild, B. (2012). Extirpolation of the Mythology that Porotic Hyperostosis is Caused by Iron Deficiency Secondary to Dietary Shift to Maize. Advances in Anthropology, 2, 157-160. doi: 10.4236/aa.2012.23018.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Agarwal, K. N., Har, N. D., & Shah, M. M. (1970). Roentgenologic changes in iron deficiency anemia. American Journal of Roentgenology, 110, 635 637.
[2] Angel, J. L. (1978). Porotic Hyperostosis in the Eastern Mediterranean. Medical College of Virginia Quarterly, 14, 10-16.
[3] Angel, J. L. (1966). Porotic hyperostosis, anemias, malarias, and marshes in the prehistoric eastern Mediterranean. Science, 153, 760763. doi:10.1126/science.153.3737.760
[4] Aslinia, F., Mazza, J. J., & S. H. Yale (2006). Megaloblastic anemia and other causes of macrocytosis. Clinical Medicine & Research, 4, 236-241. doi:10.3121/cmr.4.3.236
[5] Bishop, K. (2011). Thule paleopathology: The health concerns of an artic lifestyle. Totem: The University of Western Ontario Journal of Anthropology, 19, 50-58.
[6] Caffey, J. (1957). Cooley’s anemia: A review of the roentgenographic findings in the skeleton. American Journal of Roentgenology, 78, 381-391.
[7] Cavill, I. (2002). Erythropoiesis and iron. Best practice and research. Clinical Haematology, 15, 399-400.
[8] Cavill, I., & Ricketts, C. (1980). Human iron kinetics. In A. Jacobs, & M. Worwood (Eds.), Iron in biochemistry and medicine II (pp. 573-604). London: Academic Press.
[9] Dabbs, G. R. (2011). Health status among prehistoric Eskimos from Point Hope, Alaska. American Journal of Physical Anthropology, 146, 94-103. doi:10.1002/ajpa.21556
[10] De la Cova, C. (2011). Race, health, and disease in 19th-century-born males. American Journal of Physical Anthropology, 144, 526-537. doi:10.1002/ajpa.21434
[11] El-Najjar, M. Y., Lozoff, B., & Ryan, D. J. (1975). The paleoepidemiology of porotic hyperostosis in the American Southwest. Radiological and ecological considerations. American Journal of Roentgenology, 125, 918-924.
[12] Eng, L.-I. (1958). Chronic iron deficiency anaemia with bone changes resembling Cooley’s anemia. Acta Hematologica, 19, 263-268. doi:10.1159/000205441
[13] Fairbanks, V. F., & Beutler, E. (1972). Erythrocyte disorders—Anemias related to disturbance of hemoglobin synthesis. In W. J. Williams, E. Beutler, A. J. Erslev, & R. W. Rundles (Eds.), Hematology (pp. 305-326). New York: McGraw-Hill.
[14] Goodhart, R. S., & Shils, M. E. (1973). Modern nutrition in health and disease. Philadelphia: Lea & Febiger.
[15] Greenberg, S. A. (2009). How citation distortions create unfounded authority: Analysis of a citation network. British Medical Journal, 339, b2680. doi:10.1136/bmj.b2680
[16] Grmek, M. D. (1989). Diseases in the ancient world. Baltimore: The Johns Hopkins University Press.
[17] Hill, M. C., & Armelagos, G. J. (1990). Porotic hyperostosis in past and present perspective. In J. E. Buikstra (Ed.), A life in science: Papers in honor of J. Lawrence angel, scientific papers No. 6 (pp. 52-63). Kampsville, IL: Center for American Archeology.
[18] Jaffe, H. L. (1972). Metabolic, degenerative, and inflammatory diseases of bone and joints. Philadelphia: Lea & Febiger.
[19] Kaplan, E., & Zuelzer, W. W. (1950). Erythrocyte survival studies in childhood: II. Studies in Mediterranean anemia. Journal of Laboratory Clinical Medicine, 36, 517-523.
[20] Kattamis, C. A., Kyriazakou, M., & Chaidas, S. (1969). Favism. Clinical and biochemical data. Journal of Medical Genetics, 6, 34-41. doi:10.1136/jmg.6.1.34
[21] Lanzkowsky, P. (1968). Radiologic features of iron deficiency anemia. American Journal of Diseases of Children, 116, 16-29.
[22] Lee-Thorp, J. A. (2008). On isotopes and old bones. Archaeometry, 50, 925-950. doi:10.1111/j.1475-4754.2008.00441.x
[23] Lewis, R. (2011). Nutritional inference from paleopathological comparison of the Ootprint and Bonnell skeletal populations. Master Thesis, Lubbock: Texas Tech University.
[24] Lockyer, N., Armstrong, I. & Black, S. (2011). Bone pathology. In S. Black, & E. Ferguson (Eds.), Forensic Anthropology 2000-2010 (pp. 237-255). Boca Raton: CRC Press, Taylor & Francis. doi:10.1201/b10727-9
[25] Mensforth, R. P., Lovejoy, C. O., Lallo, J. W., & Armelagos, G. J. (1978). The role of constitutional factors, diet, and infectious disease in the etiology of porotic hyperostosis and periosteal reactions in prehistoric infants and children. Medical Anthropology, 1, 1-59. doi:10.1080/01459740.1978.9986939
[26] Meyer, A., Keough, N., Nienaber, C. W., & Steyn, M. (2011). A bioarchaeological investigation into the human remains discovered in the Chloorkop area, South Africa. International Journal of Osteoarchaeology. doi:10.1002/oa.1289
[27] Nyberg, W., Gr?sbeck, R., Saarni, M., & von Bonsdorff, B. (1961). Serum vitamin B12 levels and incidence of tapeworm anemia in a population heavily infected with Diphyllobothrium latum. American Journal of Clinical Nutrition, 9, 606-612.
[28] Oxenham, M. F., & Cavill, I. (2010). Porotic hyperostosis and cribra orbitalia: The erythropoietic response to iron-deficiency anemia. Anthropological Science, 118, 199-200. doi:10.1537/ase.100302
[29] Resnick, D. (2002). Diagnosis of bone and joint disorders (2nd ed.). Philadelphia: Saunders.
[30] Roberts, E. K., Lu, A., Bergman, T. J., & Beehner, J. C. (2012). A Bruce effect in wild geladas. Science, 335, 1222-1225. doi:10.1126/science.1213600
[31] Rothschild, B. (2000.). Porotic hyperostosis as a manifestation of deficiency? Chungara, Revista de Antropologia Chilena, 32, 85-87.
[32] Rothschild, B. M., & Martin, L. D. (2006). Skeletal impact of disease. Albuquerque: New Mexico Museum of Natural History.
[33] Rothschild, B. M., Poteat, G. B., Williams, E., & Crawford, W. L. (1994). Inflammatory sacroiliac joint pathology: Evaluation of radiologic assessment techniques. Clinical and Experimental Rheumatology, 12, 267-274.
[34] Rothschild, B. M., Rühli, F., Sebes, J., Naples, V., & Billard, M. (2005). Relationship between porotic hyperostosis and cribra orbitalia? Paleobios, 13, 4-7.
[35] Scherer, A. K., Wright, L. E., & Yoder, C. J. (2007). Bioarchaeological evidence for social and temporal differences in diet at Piedras Negras, Guatemala. Latin American Antiquity, 18, 85-104. doi:10.2307/25063087
[36] Spodick, D. H. (1975). On experts and expertise. The effect of variability in observer performance. American Journal of Cardiology, 36, 592-596. doi:10.1016/0002-9149(75)90156-3
[37] Stuart Macadam, P. L. (1989). Nutritional deficiency diseases: A survey of scurvy, rickets and iron deficiency anemia. In M. Y. Iscan, & K. A. Kennedy (Eds.), Reconstruction of life from the skeleton (pp. 210 222). New York: Liss.
[38] Stuart Macadam, P., & Kent S., (1992). Diet, demography and disease. New York: Gruyter.
[39] Temperley, I. J., & Sharp, A. A. (1962). The life span of erythrocytes in iron-deficiency anemia. Journal of Clinical Pathology, 15, 346-349. doi:10.1136/jcp.15.4.346
[40] Von Endt, D. W., & Ortner, D. J. (1982). Amino acid analysis of bone from a possible case of prehistoric iron deficiency from the American southwest. American Journal of Physical Anthropology, 59, 377385. doi:10.1002/ajpa.1330590407
[41] Walker, P. L., Bathurst, R. R., Richman, R., Gjerdrum, T., & Andrusko, V. A. (2009). The causes of porotic hyperostosis and cribra orbitalia: A reappraisal of the iron-deficiency-anemia hypothesis. American Journal of Physical Anthropology, 139, 109-125. doi:10.1002/ajpa.21031
[42] Wilbur, A. K., Farnbach, A. W., Knudson, K. J., & Buikstra, J. E. (2008). Diet, tuberculosis and the paleopathological record. Current Anthropology, 49, 963-991. doi:10.1086/592434
[43] Wright, L. E., & Chew, F. (1999). Porotic hyperostosis and paleoepidemiology: A forensic perspective on anemia among the Ancient Maya. American Anthropologist, 100, 924-939. doi:10.1525/aa.1998.100.4.924
[44] Young, L. E., Izzo, M. J., & Platzer, R. F. (1951). Hereditary spherocytosis. I. Hematologic and genetic features in 28 cases with particular reference to the osmotic and mechanical fragility of incubated erythrocytes. Blood, 6, 1073-1098.

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