Visfatin Gene Responses to 8 Weeks of Treadmill Running with or without Pistachio atlantica Liquid Extraction in Female Rat Tissues


Visfatin, a novel adipokine, was revealed to be associated with obesity and to have insulin mimetic effect that is highly expressed in visceral adipose tissue. The aim of this study was to determine the liver and kidney visfatin relative gene expression. Twenty wistar rats (6-8 weeks old and 125-135 g weight) were used. Animals were randomly assigned into saline-control (SC), saline-training (ST), and Baneh-control (BC), and Baneh-training (BT). Training groups was given exercise on a motor-driven treadmill at 25 m/min (0% grade) for 60 min/day and 5 days/week for eight weeks. Subjects were fed oral, with Baneh extraction and saline for four weeks. Visfatin relative gene expression was detected by Real-time PCR method. Also plasma was collected for glucose measurements. Results demonstrated that Baneh extraction significantly increase visfatin relative gene expression in liver (P < 0.002) and increase not significantly in kidney tissue. Exercise training significantly reduce visfatin relative gene expression in liver (P < 0.042), and reduce not significantly in kidney tissue. Plasma and liver glucose level increases by Baneh. Exercise training decreses visfatin relative gene expression and Baneh increases visfatin relative gene expression in liver and kidney. Also Baneh can increases plasma glucose and liver glucose and glycogen concentration probably due to high fatty acid and component.

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A. Ghanbari-Niaki, N. Kookandeh, S. Ahmadabad and R. Fathi, "Visfatin Gene Responses to 8 Weeks of Treadmill Running with or without Pistachio atlantica Liquid Extraction in Female Rat Tissues," Food and Nutrition Sciences, Vol. 3 No. 8, 2012, pp. 1144-1149. doi: 10.4236/fns.2012.38150.

Conflicts of Interest

The authors declare no conflicts of interest.


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