An investigation of volumetric and corpus callosum dimension to detect brain disorders


Alzheimer’s disease (AD), Mental retardation, Cerebral Palsy, and other Dementias are the neurogenerative brain disorders which are statistically proven that 2% - 3% of people affected in the world today. The proposed method considered the symptoms which stands distinct for Alzheimer’s disease. Many structural neuroimaging studies have found the atrophy of the Corpus Callosum (CC) and the decrease in brain volume in AD. The measurement, area has been extracted from the gradient mask of the image to characterize the local atrophy of the CC. The result showed decreased area of the CC in AD when compared to the control groups. The volume has also been calculated by volume rendering and voxel size measurement for the same set of control groups and was found to be reduced in the AD patients. These findings confirmed the pathology characteristics in AD of brain disorders. The system’s validity with respect to results obtained with conventional diagnosis has been examined and proved to offer better results.

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Prabakar, S. and Porkumaran, K. (2012) An investigation of volumetric and corpus callosum dimension to detect brain disorders. Journal of Biomedical Science and Engineering, 5, 369-377. doi: 10.4236/jbise.2012.57047.

Conflicts of Interest

The authors declare no conflicts of interest.


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