Microfluidic Behavior of Ternary Mixed Carrier Solvents Based on the Tube Radial Distribution in Triple-Branched Microchannels in a Microchip

Naoya Jinno, Masahiko Hashimoto, Kazuhiko Tsukagoshi

Department of Chemical Engineering and Materials Science, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Japan.
Department of Chemical Engineering and Materials Science, Faculty of Science and Engineering, Doshisha University, Kyotanabe, Japan..

DOI: 10.4236/jasmi.2012.22010                

Abstract

Microfluidic behavior of ternary mixed carrier solvents of water-acetonitrile-ethyl acetate (2:3:1 volume ratio) was examined by use of a microchip incorporating microchannels in which one wide channel was separated into three narrow channels, i.e., triple-branched microchannels. When the ternary carrier solution containing the fluorescent dyes, hydrophobic perylene (blue) and relatively hydrophilic Eosin Y (green), was fed into the wide channel under laminar flow conditions, the carrier solvent molecules or fluorescence dyes were radially distributed in the channel, forming inner (organic solvent-rich major; blue) and outer (water-rich minor; green) phases in the wide channel. And then, in the narrow channels, perylene molecules mostly appeared to flow through the center narrow channel and Eosin Y, which is distributed in the outer phases in the wide channel, flowed through the both side narrow channels. A metal ion, Cu(II) as a model, dissolved in the ternary mixed carrier solution was also examined. The Cu(II) showed fluidic behavior, transferring from the homogeneous carrier solution to the water-rich solution in the side narrow channels through the triple-branched microchannels.

Keywords

Triple-Branched Microchannels; Ternary Mixed Solvents; Fluorescence Dyes; Metal Ion; Tube Radial Distribution Phenomenon (TRDP)

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	K. Ueno, F. Kitagawa and N. Kitamura, “One-Step Electrochemical Cyanation Reaction of Pyrene in Polymer Microchannel-Electrode Chips,” Bulletin of the Chemical Society of Japan, Vol. 77, No. 7, 2011, pp. 1331-1338. doi:10.1246/bcsj.77.1331
[2]	D. R. Reyes, D. Iossifidis, P. A. Auroux and A. Manz, “Micro Total Analysis Systems. 1. Introduction, Theory, and Technology,” Analytical Chemistry, Vol. 74, No. 12, 2002, pp. 2623-2636. doi:10.1021/ac0202435
[3]	Y. Kikutani, H. Hisamoto, M. Tokeshi and T. Kitamori, “Micro Wet Analysis System Using Multi-Phase Laminar Flows in Three-Dimensional Microchannel Network,” Lab on a Chip, Vol. 4, No. 4, 2004, pp. 328-332. doi:10.1039/b400233d
[4]	A. Hibara, M. Tokeshi, K. Uchiyama, H. Hisamoto and T. Kitamori, “Integrated Multilayer Flow System on a Microchip,” Analytical Sciences, Vol. 17, No. 1, 2001, pp. 89-93. doi:10.2116/analsci.17.89
[5]	N. Kaji, Y. Okamoto, M. Tokeshi and Y. Baba, “Nanopillar, Nanoball, and Nanofibers for Highly Efficient Analysis of Biomolecules,” Chemical Society Reviews, Vol. 39, No. 3, 2010, pp. 948-956. doi:10.1039/b900410f
[6]	H. Nakamura, Y. Yamaguchi, M. Miyazaki, H. Maeda and M. Uehara, “Preparation of CdSe Nanocrystals in a Micro-Flow-Reactor,” Chemical Communications, No. 23, 2002, pp. 2844-2845. doi:10.1039/b208992k
[7]	H. Kawazumi, A. Tashiro, K. Ogino and H. Maeda, “Observation of Fluidic Behavior in a Polymethylmethacrylate-Fabricated Microchannel by a Simple Spectroscopic Analysis,” Lab on a Chip, Vol. 2, No. 1, 2002, pp. 8-10. doi:10.1039/b109058e
[8]	N. Jinno, M. Murakami, K. Mizohata, M. Hashimoto and K. Tsukagoshi, “Fluorescence Observation Supporting Capillary Chromatography Based on Tube Radial Distribution of Carrier Solvents under Laminar Flow Conditions,” Analyst, Vol. 136, No. 5, 2011, pp. 927-932. doi:10.1039/c0an00820f
[9]	N. Jinno, M. Hashimoto and K. Tsukagoshi, “Experimental Consideration of Capillary Chromatography Based on Tube Radial Distribution of Ternary Mixture Carrier Solvents under Laminar Flow Conditions,” Analytical Sciences, Vol. 27, No. 3, 2011, pp. 259-264. doi:10.2116/analsci.27.259
[10]	M. Murakami, N. Jinno, M. Hashimoto and K. Tsukagoshi, “Tube Radial Distribution Phenomenon of Ternary Mixed Solvents in a Microspace under Laminar Flow Conditions,” Analytical Sciences, Vol. 27, No. 8, 2011, pp. 793-798. doi:10.2116/analsci.27.793
[11]	S. Fujinaga, N. Jinno, M. Hashimoto and K. Tsukagoshi, “Use of Tube Radial Distribution of Ternary Mixed Carrier Solvents for Introduction of Absorption Reagent for Metal Ion Separation and Online Detection into Capillary,” Journal of Separation Science, Vol. 34, No. 20, 2011, pp. 2833-2839. doi:10.1002/jssc.201100404
[12]	N. Jinno, M. Hashimoto and K. Tsukagoshi, “Extraction of Cu(II) Based on Tube Radial Distribution of Ternary Mixed Carrier Solvent in Microchannels,” Chemistry Letters, Vol. 40, No. 6, 2011, pp. 654-655. doi:10.1246/cl.2011.654